| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
BNIP3L |
| Specificity: |
This antibody reacts specifically with BNIP3L |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Nucleus |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human BNIP3L |
| Gene ID: |
665 |
| Swiss Prot: |
O60238 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix, Can overcome the suppressors BCL-2 and BCL-XL, Inhibits apoptosis induced by BNIP3, Interacts with viral and cellular anti-apoptosis proteins, Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, May function as a tumor suppressor, The physical interaction of SPATA18/MIEAP, although high levels of BCL-XL expression will inhibit apoptosis, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria, Induces apoptosis |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
Nix BNIP3a |
| Also known as: |
BNIP3L Polyclonal Antibody |
| Other name: |
Anti-BNIP3L Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
BNIP3L |
| Short name: |
Anti-BNIP3L (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-B-cell CLL/lymphoma 2/adenovirus E1B 19kDa interacting protein 3-like (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
BNIP3L and IDBG-13074 and ENSG00000104765 and 665, BNIP3L and IDBG-635626 and ENSBTAG00000021307 and 534615, BNIP3a and NIX, Bnip3l and IDBG-175760 and ENSMUSG00000022051 and 100043324, nuclei, protein heterodimerization activity, this GO :0005515 and protein binding and molecular function this GO :0005521 and lamin binding and molecular function this GO :0005635 and nuclear envelope and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005740 and mitochondrial envelope and cellular component this GO :0005741 and mitochondrial outer membrane and cellular component this GO :0005783 and endoplasmic reticulum and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016032 and viral process and biological process this GO :0031224 and intrinsic component of membrane and cellular component this GO :0035694 and mitochondrial protein catabolic process and biological process this GO :0042802 and identical protein binding and molecular function this GO :0042803 and protein homodimerization activity and molecular function this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0046982 and protein heterodimerization activity and molecular function this GO :0051607 and defense response to virus and biological process this GO :0097345 and mitochondrial outer membrane permeabilization and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding and also this GO :0005521 : lamin binding and also this GO :0042802 : identical protein binding and also this GO :0042803 : protein homodimerization activity and also this GO :0046982 : protein heterodimerization activity, this GO :0005521 : lamin binding, this GO :0042802 : identical protein binding, this GO :0042803 : protein homodimerization activity, this GO :0046982 : protein heterodimerization activity, 12177, 102641641, BCL2/adenovirus E1B 19kDa interacting protein 3-like |
| Identity: |
1085 |
| Gene: |
BNIP3L |
More about : BNIP3L |
| Long gene name: |
BCL2 interacting protein 3 like |
| Synonyms gene name: |
BCL2/adenovirus E1B 19kDa interacting protein 3 like |
| Locus: |
8p21, 2 |
| Discovery year: |
1997-07-01 |
| GenBank acession: |
AB004788 |
| Entrez gene record: |
665 |
| Pubmed identfication: |
9523198 9973195 |
| RefSeq identity: |
NM_004331 |
| Havana BLAST/BLAT: |
OTTHUMG00000099433 |