| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
VAV1 Tyr160 |
| Specificity: |
This antibody reacts specifically with VAV1 (Tyr160) |
| Modification: |
Phosphorylation |
| Modification site: |
Tyr160 |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Intracellular |
| Antigen Source: |
KLH conjugated synthetic phosphopeptide derived from human VAV1 around the phosphorylation site of Tyr160 |
| Gene ID: |
7409 |
| Swiss Prot: |
P15498 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
thus leading to cell differentiation and/or proliferation, Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Also known as: |
VAV1 (Tyr160) Polyclonal Antibody |
| Other name: |
Anti-VAV1 (Tyr160) Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
VAV1 (Tyr160) |
| Short name: |
Anti-VAV1 (Tyr160) (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-vav 1 guanine nucleotide exchange factor (Tyr160) (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
Cell surfaces, DNA-templated and biological process this GO :0006909 and pha this GO cytosis and biological process this GO :0006955 and immune response and biological process this GO :0007173 and epidermal growth factor receptor signaling pathway and biological process this GO :0007186 and G-protein coupled receptor signaling pathway and biological process this GO :0007229 and integrin-mediated signaling pathway and biological process this GO :0007264 and small GTPase mediated signal transduction and biological process this GO :0007596 and blood coagulation and biological process this GO :0008543 and fibroblast growth factor receptor signaling pathway and biological process this GO :0030168 and platelet activation and biological process this GO :0030593 and neutrophil chemotaxis and biological process this GO :0030676 and Rac guanyl-nucleotide exchange factor activity and molecular function this GO :0031295 and T cell costimulation and biological process this GO :0032314 and regulation of Rac GTPase activity and biological process this GO :0032321 and positive regulation of Rho GTPase activity and biological process this GO :0032855 and positive regulation of Rac GTPase activity and biological process this GO :0035023 and regulation of Rho protein signal transduction and biological process this GO :0035556 and intracellular signal transduction and biological process this GO :0038095 and Fc-epsilon receptor signaling pathway and biological process this GO :0038096 and Fc-gamma receptor signaling pathway involved in pha this GO cytosis and biological process this GO :0042110 and T cell activation and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043087 and regulation of GTPase activity and biological process this GO :0043547 and positive regulation of GTPase activity and biological process this GO :0045087 and innate immune response and biological process this GO :0045785 and positive regulation of cell adhesion and biological process this GO :0046872 and metal ion binding and molecular function this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0048015 and phosphatidylinositol-mediated signaling and biological process this GO :0051056 and regulation of small GTPase mediated signal transduction and biological process this GO :0072593 and reactive oxygen species metabolic process and biological process this GO :0097190 and apoptotic signaling pathway and biological process, VAV, VAV1 and IDBG-22055 and ENSG00000141968 and 7409, VAV1 and IDBG-643888 and ENSBTAG00000039160 and, Vav1 and IDBG-194093 and ENSMUSG00000034116 and 22324, metal ion binding, this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0005085 and guanyl-nucleotide exchange factor activity and molecular function this GO :0005089 and Rho guanyl-nucleotide exchange factor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005911 and cell-cell junction and cellular component this GO :0006355 and regulation of transcription, this GO :0003700 : sequence-specific DNA binding transcription factor activity, this GO :0003700 : sequence-specific DNA binding transcription factor activity and also this GO :0005085 : guanyl-nucleotide exchange factor activity and also this GO :0005089 : Rho guanyl-nucleotide exchange factor activity and also this GO :0005515 : protein binding and also this GO :0030676 : Rac guanyl-nucleotide exchange factor activity and also this GO :0046872 : metal ion binding, this GO :0005085 : guanyl-nucleotide exchange factor activity, this GO :0005089 : Rho guanyl-nucleotide exchange factor activity, this GO :0005515 : protein binding, this GO :0030676 : Rac guanyl-nucleotide exchange factor activity, this GO :0046872 : metal ion binding, vav 1 guanine nucleotide exchange factor |
| Identity: |
12657 |
| Gene: |
VAV1 |
More about : VAV1 |
| Long gene name: |
vav guanine nucleotide exchange factor 1 |
| Synonyms gene: |
VAV |
| Synonyms gene name: |
vav 1 oncogene vav 1 guanine nucleotide exchange factor |
| Locus: |
19p13, 3 |
| Discovery year: |
1991-03-04 |
| Entrez gene record: |
7409 |
| Pubmed identfication: |
9438848 |
| Classification: |
Rho guanine nucleotide exchange factors Pleckstrin homology domain containing SH2 domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000181965 |