| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
NF1 |
| Specificity: |
This antibody reacts specifically with NF1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human Neurofibromin 1 |
| Gene ID: |
4763 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Alternatively spliced transcript variants encoding different isoforms have also been described for this gene, Jul 2008], Mutations in this gene have been linked to neurofibromatosis type 1, The mRNA for this gene is subject to RNA editing (CGA>, [provided by RefSeq, juvenile myelomonocytic leukemia and Watson syndrome, Arg1306Term) resulting in premature translation termination, This gene product appears to function as a negative regulator of the ras signal transduction pathway, UGA-> |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Also known as: |
NF1 Polyclonal Antibody |
| Other name: |
Anti-NF1 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
NF1 |
| Short name: |
Anti-NF1 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-neurofibromin 1 (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
GABAergic and biological process this GO :0032318 and regulation of Ras GTPase activity and biological process this GO :0032320 and positive regulation of Ras GTPase activity and biological process this GO :0035021 and negative regulation of Rac protein signal transduction and biological process this GO :0042060 and wound healing and biological process this GO :0042127 and regulation of cell proliferation and biological process this GO :0042992 and negative regulation of transcription factor import into nucleus and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043407 and negative regulation of MAP kinase activity and biological process this GO :0043409 and negative regulation of MAPK cascade and biological process this GO :0043473 and pigmentation and biological process this GO :0043525 and positive regulation of neuron apoptotic process and biological process this GO :0043535 and regulation of blood vessel endothelial cell migration and biological process this GO :0045124 and regulation of bone resorption and biological process this GO :0045671 and negative regulation of osteoclast differentiation and biological process this GO :0045685 and regulation of glial cell differentiation and biological process this GO :0045762 and positive regulation of adenylate cyclase activity and biological process this GO :0045765 and regulation of angiogenesis and biological process this GO :0046580 and negative regulation of Ras protein signal transduction and biological process this GO :0046929 and negative regulation of neurotransmitter secretion and biological process this GO :0048147 and negative regulation of fibroblast proliferation and biological process this GO :0048169 and regulation of long-term neuronal synaptic plasticity and biological process this GO :0048485 and sympathetic nervous system development and biological process this GO :0048593 and camera-type eye morphogenesis and biological process this GO :0048712 and negative regulation of astrocyte differentiation and biological process this GO :0048715 and negative regulation of oli this GO dendrocyte differentiation and biological process this GO :0048745 and smooth muscle tissue development and biological process this GO :0048844 and artery morphogenesis and biological process this GO :0048853 and forebrain morphogenesis and biological process this GO :0050890 and cognition and biological process this GO :0051056 and regulation of small GTPase mediated signal transduction and biological process this GO :1902043 and positive regulation of extrinsic apoptotic signaling pathway via death domain receptors and biological process this GO :2001241 and positive regulation of extrinsic apoptotic signaling pathway in absence of ligand and biological process, NF1 and IDBG-39462 and ENSG00000196712 and 102725369, NF1 and IDBG-631285 and ENSBTAG00000011829 and 280877, NFNS and VRNF and WSS, Nf1 and IDBG-203454 and ENSMUSG00000020716 and 18015, nuclei, phosphatidylcholine binding, this GO :0000165 and MAPK cascade and biological process this GO :0001649 and osteoblast differentiation and biological process this GO :0001656 and metanephros development and biological process this GO :0001666 and response to hypoxia and biological process this GO :0001889 and liver development and biological process this GO :0001937 and negative regulation of endothelial cell proliferation and biological process this GO :0001938 and positive regulation of endothelial cell proliferation and biological process this GO :0001952 and regulation of cell-matrix adhesion and biological process this GO :0001953 and negative regulation of cell-matrix adhesion and biological process this GO :0005096 and GTPase activator activity and molecular function this GO :0005099 and Ras GTPase activator activity and molecular function this GO :0005488 and binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005622 and intracellular and cellular component this GO :0005634 and nucleus and cellular component this GO :0005730 and nucleolus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0006469 and negative regulation of protein kinase activity and biological process this GO :0007154 and cell communication and biological process this GO :0007165 and signal transduction and biological process this GO :0007265 and Ras protein signal transduction and biological process this GO :0007406 and negative regulation of neuroblast proliferation and biological process this GO :0007420 and brain development and biological process this GO :0007422 and peripheral nervous system development and biological process this GO :0007507 and heart development and biological process this GO :0007519 and skeletal muscle tissue development and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0008429 and phosphatidylethanolamine binding and molecular function this GO :0008542 and visual learning and biological process this GO :0008625 and extrinsic apoptotic signaling pathway via death domain receptors and biological process this GO :0014044 and Schwann cell development and biological process this GO :0014065 and phosphatidylinositol 3-kinase signaling and biological process this GO :0016020 and membrane and cellular component this GO :0016525 and negative regulation of angiogenesis and biological process this GO :0021510 and spinal cord development and biological process this GO :0021897 and forebrain astrocyte development and biological process this GO :0021915 and neural tube development and biological process this GO :0021987 and cerebral cortex development and biological process this GO :0022011 and myelination in peripheral nervous system and biological process this GO :0030036 and actin cytoskeleton organization and biological process this GO :0030198 and extracellular matrix organization and biological process this GO :0030199 and collagen fibril organization and biological process this GO :0030325 and adrenal gland development and biological process this GO :0030336 and negative regulation of cell migration and biological process this GO :0030424 and axon and cellular component this GO :0030425 and dendrite and cellular component this GO :0031210 and phosphatidylcholine binding and molecular function this GO :0031235 and intrinsic component of the cytoplasmic side of the plasma membrane and cellular component this GO :0032228 and regulation of synaptic transmission, this GO :0005096 : GTPase activator activity, this GO :0005096 : GTPase activator activity and also this GO :0005099 : Ras GTPase activator activity and also this GO :0005488 : binding and also this GO :0005515 : protein binding and also this GO :0008429 : phosphatidylethanolamine binding and also this GO :0031210 : phosphatidylcholine binding, this GO :0005099 : Ras GTPase activator activity, this GO :0005488 : binding, this GO :0005515 : protein binding, this GO :0008429 : phosphatidylethanolamine binding, this GO :0031210 : phosphatidylcholine binding, 4763, neurofibromin 1 |
| Identity: |
7765 |
| Gene: |
NF1 |
More about : NF1 |
| Long gene name: |
neurofibromin 1 |
| Synonyms name: |
neurofibromatosis von Recklinghausen disease Watson disease |
| Locus: |
17q11, 2 |
| Discovery year: |
1986-01-01 |
| Entrez gene record: |
4763 |
| Pubmed identfication: |
1715669 |
| RefSeq identity: |
NM_000267 |
| Havana BLAST/BLAT: |
OTTHUMG00000132871 |
| Locus Specific Databases: |
LOVD - Mendelian genes LRG_214 |