| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
JMJD1B |
| Specificity: |
This antibody reacts specifically with JMJD1B |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human JMJD1B |
| Gene ID: |
51780 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
5qNCA (5q Nuclear Co-Activator) or C5orf7, Eptopic expression of JMJD1B exhibits growth suppressive activities, Expressed in a wide variety of tissues, JMJD1B functions as a histone demethylase and, JMJD1B localizes to the nucleus and contains one JMJC domain and a C-terminal zinc finger motif, The gene encoding human JMJD1B is located within the 5q region of the genome that is often deleted in myeloid leukemias and myelodysplasias, This implies that JMJD1B may function as a tumor suppressor of myeloid leukemia, This suggests that JMJD1B plays a central role in the histone code, also known as KDM3B, demethylates lysine-9 of Histone H3, further supporting a role for JMJD1B in tumor suppression, is a member of the JHDM2 histone demethylase family of proteins, using iron as a cofactor, JMJD1B (jumonji domain containing 1B) |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
KIAA1082 NET22 |
| Also known as: |
JMJD1B Polyclonal Antibody |
| Other name: |
Anti-JMJD1B Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
JMJD1B |
| Short name: |
Anti-JMJD1B (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-JMJD1B (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
1337 |
| Gene: |
KDM3B |
More about : KDM3B |
| Long gene name: |
lysine demethylase 3B |
| Synonyms gene: |
C5orf7 JMJD1B |
| Synonyms gene name: |
chromosome 5 open reading frame 7 jumonji domain containing 1B lysine (K)-specific demethylase 3B |
| Locus: |
5q31, 2 |
| Discovery year: |
2000-07-21 |
| GenBank acession: |
AF251039 |
| Entrez gene record: |
51780 |
| Pubmed identfication: |
15138608 |
| RefSeq identity: |
NM_016604 |
| Classification: |
Lysine demethylases |
| Havana BLAST/BLAT: |
OTTHUMG00000163469 |