| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
TOPO II Alpha Ser1106 |
| Specificity: |
This antibody reacts specifically with TOPO II Alpha (Ser1106) |
| Modification: |
Phosphorylation |
| Modification site: |
Ser1106 |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic phosphopeptide derived from human TOPO II Alpha around the phosphorylation site of Ser1106 |
| Gene ID: |
7153 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, Reduced activity of this enzyme may also play a role in ataxia-telangiectasia, The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance, The gene encoding this form, This nuclear enzyme is involved in processes such as chromosome condensation, Two forms of this enzyme exist as likely products of a gene duplication event, alpha, an enzyme that controls and alters the topologic states of DNA during transcription, and the relief of torsional stress that occurs during DNA transcription and replication, chromatid separation, is localized to chromsome 17 and the beta gene is localized to chromosome 3, thus altering the topology of DNA, This gene encodes a DNA topoisomerase |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
DNA Topoisomerase2, DNA topoisomerase 2-alpha, DNA topoisomerase II, DNA topoisomerase II 170 kD, DNA topoisomerase II alpha isozyme, TOP 2A, TOP2, TOP2A, TOP2A_HUMAN, TP2A, TopII alpha, Topo II alpha, Topoisomerase DNA II alpha 170kDa, Topoisomerase II alpha 170 kDa, alpha isozyme, &hellip, ¡, DNA topoisomeraseâ, alpha |
| Also known as: |
TOPO II Alpha (Ser1106) Antibody |
| Other name: |
Anti-TOPO II Alpha (Ser1106) |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Description: |
- or alpha protein sometimes glycoprotein present in blood, The Anti-TOPO II Alpha (Ser1106) Fluor 594 is a &alpha |
| Gene target: |
TOPO II Alpha (Ser1106) |
| Short name: |
Anti-TOPO II Alpha (Ser1106) Fluor 594 |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-TOPO II a (Ser1106) |