| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
IRF7 |
| Specificity: |
This antibody reacts specifically with IRF7 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Nucleus, Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human IRF7 |
| Gene ID: |
3665 |
| Swiss Prot: |
Q92985 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency, Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages, Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, MyD88-dependent pathway, MyD88-independent pathway and the TLR-activated, Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters, Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase, This induces a conformational change, becomes phosphorylated by IKBKE and TBK1 kinases, double-stranded RNA (dsRNA), either directly or through induction of IRF1, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes, or toll-like receptor (TLR) signaling, Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Also known as: |
IRF7 Polyclonal Antibody |
| Other name: |
Anti-IRF7 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
IRF7 |
| Short name: |
Anti-IRF7 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-interferon regulatory factor 7 (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
BT, DNA-templated and biological process this GO :0006366 and transcription from RNA polymerase II promoter and biological process this GO :0006974 and cellular response to DNA damage stimulus and biological process this GO :0009615 and response to virus and biological process this GO :0010008 and endosome membrane and cellular component this GO :0016064 and immunoglobulin mediated immune response and biological process this GO :0019043 and establishment of viral latency and biological process this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0032479 and regulation of type I interferon production and biological process this GO :0032481 and positive regulation of type I interferon production and biological process this GO :0032607 and interferon-alpha production and biological process this GO :0032608 and interferon-beta production and biological process this GO :0032727 and positive regulation of interferon-alpha production and biological process this GO :0032728 and positive regulation of interferon-beta production and biological process this GO :0034124 and regulation of MyD88-dependent toll-like receptor signaling pathway and biological process this GO :0034127 and regulation of MyD88-independent toll-like receptor signaling pathway and biological process this GO :0034138 and toll-like receptor 3 signaling pathway and biological process this GO :0034142 and toll-like receptor 4 signaling pathway and biological process this GO :0034162 and toll-like receptor 9 signaling pathway and biological process this GO :0035666 and TRIF-dependent toll-like receptor signaling pathway and biological process this GO :0039530 and MDA-5 signaling pathway and biological process this GO :0045087 and innate immune response and biological process this GO :0045351 and type I interferon biosynthetic process and biological process this GO :0045655 and regulation of monocyte differentiation and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0050776 and regulation of immune response and biological process this GO :0060333 and interferon-gamma-mediated signaling pathway and biological process this GO :0060337 and type I interferon signaling pathway and biological process this GO :0060340 and positive regulation of type I interferon-mediated signaling pathway and biological process this GO :2000110 and negative regulation of macrophage apoptotic process and biological process, IRF-7H and IRF7A and IRF7B and IRF7C and IRF7H, IRF7 and IDBG-17225 and ENSG00000185507 and 3665, Irf7 and IDBG-212081 and ENSMUSG00000025498 and 54123, nuclei, protein binding, this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0000975 and regulatory region DNA binding and molecular function this GO :0000979 and RNA polymerase II core promoter sequence-specific DNA binding and molecular function this GO :0000982 and RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity and molecular function this GO :0002224 and toll-like receptor signaling pathway and biological process this GO :0002756 and MyD88-independent toll-like receptor signaling pathway and biological process this GO :0002819 and regulation of adaptive immune response and biological process this GO :0003677 and DNA binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006355 and regulation of transcription, this GO :0000975 : regulatory region DNA binding, this GO :0000975 : regulatory region DNA binding and also this GO :0000979 : RNA polymerase II core promoter sequence-specific DNA binding and also this GO :0000982 : RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity and also this GO :0003677 : DNA binding and also this GO :0003700 : sequence-specific DNA binding transcription factor activity and also this GO :0005515 : protein binding, this GO :0000979 : RNA polymerase II core promoter sequence-specific DNA binding, this GO :0000982 : RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity, this GO :0003677 : DNA binding, this GO :0003700 : sequence-specific DNA binding transcription factor activity, this GO :0005515 : protein binding, 96672 and IDBG-645560 and ENSBTAG00000047680 and 100125591, interferon regulatory factor 7 |
| Identity: |
6122 |
| Gene: |
IRF7 |
More about : IRF7 |
| Long gene name: |
interferon regulatory factor 7 |
| Locus: |
11p15, 5 |
| Discovery year: |
1996-11-13 |
| GenBank acession: |
U53830 |
| Entrez gene record: |
3665 |
| RefSeq identity: |
NM_001572 |
| Havana BLAST/BLAT: |
OTTHUMG00000132019 |