| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
SNX1 |
| Specificity: |
This antibody reacts specifically with SNX1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Membrane bound |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human SNX1/Sorting nexin1 |
| Gene ID: |
6642 |
| Swiss Prot: |
Q13596 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex, Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:19816406, Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3, Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R (PubMed:16407403, M6PR and SORT1) and Shiginella dysenteria toxin stxB, Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi (PubMed:12198132, Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation, PubMed:15498486, PubMed:17101778, PubMed:17550970, PubMed:18088323, PubMed:20070609), PubMed:21040701), PubMed:23085988), Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (PubMed:23152498), The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling, The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable), the function is dependent on GEF activity of KALRN (PubMed:20604901), 5)P2) (PubMed:12198132), 5-bisphosphate (PtdIns(3, Involved in several stages of intracellular trafficking |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
SNX1A MGC8664 HsT17379 Vps5 |
| Also known as: |
SNX1 Polyclonal Antibody |
| Other name: |
Anti-SNX1 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
SNX1 |
| Short name: |
Anti-SNX1 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-sorting nexin 1 (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
HsT17379 and VPS5, Plasma membranes, SNX1 and IDBG-16207 and ENSG00000028528 and 6642, SNX1 and IDBG-646500 and ENSBTAG00000002014 and 512029, Snx1 and IDBG-178734 and ENSMUSG00000032382 and 56440, endosome to this GO lgi and biological process this GO :0043231 and intracellular membrane-bounded organelle and cellular component this GO :0045732 and positive regulation of protein catabolic process and biological process, phosphatidylinositol binding, this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005768 and endosome and cellular component this GO :0005769 and early endosome and cellular component this GO :0005794 and this GO lgi apparatus and cellular component this GO :0005829 and cytosol and cellular component this GO :0006886 and intracellular protein transport and biological process this GO :0006897 and endocytosis and biological process this GO :0010008 and endosome membrane and cellular component this GO :0016020 and membrane and cellular component this GO :0016023 and cytoplasmic membrane-bounded vesicle and cellular component this GO :0016197 and endosomal transport and biological process this GO :0030904 and retromer complex and cellular component this GO :0031901 and early endosome membrane and cellular component this GO :0034498 and early endosome to this GO lgi transport and biological process this GO :0035091 and phosphatidylinositol binding and molecular function this GO :0042147 and retrograde transport, this GO :0005515 : protein binding, this GO :0005515 : protein binding and also this GO :0035091 : phosphatidylinositol binding, this GO :0035091 : phosphatidylinositol binding, sorting nexin 1 |
| Identity: |
11172 |
| Gene: |
SNX1 |
More about : SNX1 |
| Long gene name: |
sorting nexin 1 |
| Locus: |
15q22, 31 |
| Discovery year: |
1996-07-17 |
| GenBank acession: |
BC000357 |
| Entrez gene record: |
6642 |
| Pubmed identfication: |
8638121 |
| RefSeq identity: |
NM_003099 |
| Classification: |
Sorting nexins PX-BAR domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000172436 |