| Long name: |
ALEXA FLUOR 647 Conjugated, SNX1 Polyclonal Antibody |
| Also known as: |
Anti-SNX1 PAb ALEXA FLUOR 647 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
647, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
SNX1 |
| Specificity: |
This is a highly specific antibody against SNX1 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
420-470/522 |
| Subcellular location: |
Membrane bound |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human SNX1/Sorting nexin1 |
| Gene ID Number: |
6642 |
| Swiss Prot: |
Q13596 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex, Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:19816406, Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3, Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R (PubMed:16407403, M6PR and SORT1) and Shiginella dysenteria toxin stxB, Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi (PubMed:12198132, Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation, PubMed:15498486, PubMed:17101778, PubMed:17550970, PubMed:18088323, PubMed:20070609), PubMed:21040701), PubMed:23085988), Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (PubMed:23152498), The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling, The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable), the function is dependent on GEF activity of KALRN (PubMed:20604901), 5)P2) (PubMed:12198132), 5-bisphosphate (PtdIns(3, Involved in several stages of intracellular trafficking |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
650nm/665nm |
| Synonyms: |
SNX1A MGC8664 HsT17379 Vps5 |
| Properties: |
ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the SNX1 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 647, Alexa Fluor |
| Gene target: |
SNX1 |
| Short name: |
SNX1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 647 |
| Alternative name: |
ALEXA FLUOR 647, sorting nexin 1 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
HsT17379 and VPS5, Plasma membranes, SNX1 and IDBG-16207 and ENSG00000028528 and 6642, SNX1 and IDBG-646500 and ENSBTAG00000002014 and 512029, Snx1 and IDBG-178734 and ENSMUSG00000032382 and 56440, endosome to this GO lgi and biological process this GO :0043231 and intracellular membrane-bounded organelle and cellular component this GO :0045732 and positive regulation of protein catabolic process and biological process, phosphatidylinositol binding, this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005768 and endosome and cellular component this GO :0005769 and early endosome and cellular component this GO :0005794 and this GO lgi apparatus and cellular component this GO :0005829 and cytosol and cellular component this GO :0006886 and intracellular protein transport and biological process this GO :0006897 and endocytosis and biological process this GO :0010008 and endosome membrane and cellular component this GO :0016020 and membrane and cellular component this GO :0016023 and cytoplasmic membrane-bounded vesicle and cellular component this GO :0016197 and endosomal transport and biological process this GO :0030904 and retromer complex and cellular component this GO :0031901 and early endosome membrane and cellular component this GO :0034498 and early endosome to this GO lgi transport and biological process this GO :0035091 and phosphatidylinositol binding and molecular function this GO :0042147 and retrograde transport, this GO :0005515 : protein binding, this GO :0005515 : protein binding and also this GO :0035091 : phosphatidylinositol binding, this GO :0035091 : phosphatidylinositol binding, sorting nexin 1 |
| Identity: |
11172 |
| Gene: |
SNX1 |
More about : SNX1 |
| Long gene name: |
sorting nexin 1 |
| Locus: |
15q22, 31 |
| Discovery year: |
1996-07-17 |
| GenBank acession: |
BC000357 |
| Entrez gene record: |
6642 |
| Pubmed identfication: |
8638121 |
| RefSeq identity: |
NM_003099 |
| Classification: |
Sorting nexins PX-BAR domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000172436 |