| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
RET |
| Specificity: |
This antibody reacts specifically with RET |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Helical |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human RET |
| Gene ID: |
5979 |
| Swiss Prot: |
P07949 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Active in the absence of ligand, Acts as a dependence receptor, ITGB1 and ITGB3)-dependent manner, Involved in the development of the neural crest, Mediator of several diseases such as neuroendocrine cancers, Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e, Phosphorylates PTK2/FAK1, Regulates both cell death/survival balance and positional information, Regulates nociceptor survival and size, Required for the molecular mechanisms orchestration during intestine organogenesis, Triggers the differentiation of rapidly adapting (RA) mechanoreceptors, a major component of the gut-associated lymphoid tissue, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands, and promotes the formation of Peyer's patch-like structures, but triggers apoptosis in absence of GDNF, cell migration, in the presence of the ligand GDNF in somatotrophs (within pituitary), involved in the development of enteric nervous system and renal organogenesis during embryonic life, neuronal navigation, promotes survival and down regulates growth hormone (GH) production, these diseases are characterized by aberrant integrins-regulated cell migration, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage, Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, g |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
PTC CDHF12 RET51 CDHR16 |
| Also known as: |
RET Polyclonal Antibody |
| Other name: |
Anti-RET Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
RET |
| Short name: |
Anti-RET (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-ret proto-oncogene (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
CDHF12 and CDHR16 and HSCR1 and MEN2A and MEN2B and MTC1 and PTC and RET-ELE1 and RET51, DNA-templated and biological process this GO :0048265 and response to pain and biological process this GO :0048484 and enteric nervous system development and biological process this GO :0050770 and regulation of axonogenesis and biological process this GO :0060041 and retina development in camera-type eye and biological process this GO :0060384 and innervation and biological process this GO :0061146 and Peyer's patch morphogenesis and biological process this GO :0071300 and cellular response to retinoic acid and biological process this GO :0072300 and positive regulation of metanephric glomerulus development and biological process this GO :0097021 and lymphocyte migration into lymphoid organs and biological process this GO :2001241 and positive regulation of extrinsic apoptotic signaling pathway in absence of ligand and biological process, Plasma membranes, RET and IDBG-628722 and ENSBTAG00000000570 and 515924, RET and IDBG-71064 and ENSG00000165731 and 5979, Ret and IDBG-181393 and ENSMUSG00000030110 and 19713, this GO :0000165 and MAPK cascade and biological process this GO :0001657 and ureteric bud development and biological process this GO :0001755 and neural crest cell migration and biological process this GO :0001838 and embryonic epithelial tube formation and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0004714 and transmembrane receptor protein tyrosine kinase activity and molecular function this GO :0004872 and receptor activity and molecular function this GO :0005509 and calcium ion binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006919 and activation of cysteine-type endopeptidase activity involved in apoptotic process and biological process this GO :0007156 and homophilic cell adhesion and biological process this GO :0007158 and neuron cell-cell adhesion and biological process this GO :0007165 and signal transduction and biological process this GO :0007169 and transmembrane receptor protein tyrosine kinase signaling pathway and biological process this GO :0007399 and nervous system development and biological process this GO :0007497 and posterior midgut development and biological process this GO :0010008 and endosome membrane and cellular component this GO :0010976 and positive regulation of neuron projection development and biological process this GO :0014042 and positive regulation of neuron maturation and biological process this GO :0016020 and membrane and cellular component this GO :0016772 and transferase activity, this GO :0004672 : protein kinase activity, this GO :0004672 : protein kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0004714 : transmembrane receptor protein tyrosine kinase activity and also this GO :0004872 : receptor activity and also this GO :0005509 : calcium ion binding and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0016772 : transferase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0004714 : transmembrane receptor protein tyrosine kinase activity, this GO :0004872 : receptor activity, this GO :0005509 : calcium ion binding, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0016772 : transferase activity, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups, transferring phosphorus-containing groups and molecular function this GO :0018108 and peptidyl-tyrosine phosphorylation and biological process this GO :0030155 and regulation of cell adhesion and biological process this GO :0030182 and neuron differentiation and biological process this GO :0030335 and positive regulation of cell migration and biological process this GO :0033619 and membrane protein proteolysis and biological process this GO :0033630 and positive regulation of cell adhesion mediated by integrin and biological process this GO :0035799 and ureter maturation and biological process this GO :0042493 and response to drug and biological process this GO :0042551 and neuron maturation and biological process this GO :0043235 and receptor complex and cellular component this GO :0045121 and membrane raft and cellular component this GO :0045793 and positive regulation of cell size and biological process this GO :0045893 and positive regulation of transcription, ret proto-oncogene |
| Identity: |
9967 |
| Gene: |
RET |
More about : RET |
| Long gene name: |
ret proto-oncogene |
| Synonyms gene: |
HSCR1 MEN2A MTC1 MEN2B |
| Synonyms gene name: |
multiple endocrine neoplasia and medullary thyroid carcinoma 1 Hirschsprung disease 1 |
| Synonyms name: |
cadherin-related family member 16 RET receptor tyrosine kinase rearranged during transfection |
| Locus: |
10q11, 21 |
| Discovery year: |
1990-07-15 |
| GenBank acession: |
BC004257 |
| Entrez gene record: |
5979 |
| Pubmed identfication: |
2687772 1611909 |
| RefSeq identity: |
NM_020975 |
| Classification: |
Cadherin related Receptor Tyrosine Kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000018024 |
| Locus Specific Databases: |
LRG_518 |