| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
SIRP Alpha |
| Specificity: |
This antibody reacts specifically with SIRP Alpha |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human CD172a |
| Gene ID: |
140885 |
| Swiss Prot: |
P78324 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Acts as docking protein and induces translocation of PTPN6, CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells, Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity), Mediates negative regulation of phagocytosis, PTPN11 and other binding partners from the cytosol to the plasma membrane, Supports adhesion of cerebellar neurons, growth factors or insulin, mast cell activation and dendritic cell activation, neurite outgrowth and glial cell attachment, Immunoglobulin-like cell surface receptor for CD47 |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
SHPS1 SIRP MYD-1 BIT P84 SHPS-1 SIRPalpha CD172a SIRPalpha2 MFR SIRP-ALPHA-1 |
| Also known as: |
SIRP Alpha Polyclonal Antibody |
| Other name: |
Anti-SIRP Alpha Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Description: |
- or alpha protein sometimes glycoprotein present in blood, The Anti-SIRP Alpha (Polyclonal) Fluor 594 is a &alpha |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
SIRP Alpha |
| Short name: |
Anti-SIRP Alpha (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-SIRP a (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
9662 |
| Gene: |
SIRPA |
More about : SIRPA |
| Long gene name: |
signal regulatory protein alpha |
| Synonyms gene: |
PTPNS1 |
| Synonyms gene name: |
non-receptor type substrate 1 signal-regulatory protein alpha , protein tyrosine phosphatase |
| Locus: |
20p13 |
| Discovery year: |
1999-03-19 |
| GenBank acession: |
D86043 |
| Entrez gene record: |
140885 |
| Pubmed identfication: |
9070220 9062191 16339511 |
| RefSeq identity: |
NM_080792 |
| Classification: |
C1-set domain containing CD molecules Signal regulatory proteins V-set domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000031682 |