| Long name: |
SIRP Alpha Primary Polyclonal Antibody |
| Also known as: |
SIRP Alpha PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
SIRP Alpha |
| Specificity: |
This is a highly specific antibody against SIRP Alpha |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
165-215/504 |
| Subcellular location: |
Extracellular |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human CD172a |
| Gene ID number: |
140885 |
| Swiss Prot: |
P78324 |
| Tested Applications: |
FCM, IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
FCM(1:20-100), IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Acts as docking protein and induces translocation of PTPN6, CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells, Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity), Mediates negative regulation of phagocytosis, PTPN11 and other binding partners from the cytosol to the plasma membrane, Supports adhesion of cerebellar neurons, growth factors or insulin, mast cell activation and dendritic cell activation, neurite outgrowth and glial cell attachment, Immunoglobulin-like cell surface receptor for CD47 |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
Brain Ig-like molecule with tyrosine-based activation motifs, CD172 antigen-like family member A, CD172A, Inhibitory receptor SHPS-1, MFR, MYD-1, MYD1, Macrophage fusion receptor, MyD-1 antigen, P84, PTPNS1, SHP substrate 1, SHPS-1, SHPS1, SIRP, SIRPA, Signal-regulatory protein alpha-1, Signal-regulatory protein alpha-2, Signal-regulatory protein alpha-3, Sirp-alpha-1, Sirp-alpha-2, Sirp-alpha-3, Tyrosine-protein phosphatase non-receptor type substrate 1, BIT |
| Description: |
- or alpha protein sometimes glycoprotein present in blood, The SIRP Alpha Antibody is a &alpha |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
SIRP Alpha |
| Short name: |
SIRP Alpha Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
SIRP a (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
9662 |
| Gene: |
SIRPA |
More about : SIRPA |
| Long gene name: |
signal regulatory protein alpha |
| Synonyms gene: |
PTPNS1 |
| Synonyms gene name: |
non-receptor type substrate 1 signal-regulatory protein alpha , protein tyrosine phosphatase |
| Synonyms: |
SHPS1 SIRP MYD-1 BIT P84 SHPS-1 SIRPalpha CD172a SIRPalpha2 MFR SIRP-ALPHA-1 |
| Locus: |
20p13 |
| Discovery year: |
1999-03-19 |
| GenBank acession: |
D86043 |
| Entrez gene record: |
140885 |
| Pubmed identfication: |
9070220 9062191 16339511 |
| RefSeq identity: |
NM_080792 |
| Classification: |
C1-set domain containing CD molecules Signal regulatory proteins V-set domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000031682 |