| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Langerin/CD207 |
| Specificity: |
This antibody reacts specifically with Langerin/CD207 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human CD207 |
| Gene ID: |
50489 |
| Swiss Prot: |
Q9UJ71 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation, Binds to sulfated as well as mannosylated glycans, Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells, Induces the formation of Birbeck granules (BGs), Major receptor on primary Langerhans cells for Candida species, Protects against human immunodeficiency virus-1 (HIV-1) infection, Saccharomyces species, and Malassezia furfur, is a potent regulator of membrane superimposition and zippering, keratan sulfate (KS) and beta-glucans, Calcium-dependent lectin displaying mannose-binding specificity |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
Langerin CLEC4K |
| Also known as: |
Langerin/CD207 Polyclonal Antibody |
| Other name: |
Anti-Langerin/CD207 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
Langerin/CD207 |
| Short name: |
Anti-Langerin/CD207 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, langerin (polyclonal), antibody to-Langerin/CD207 molecule |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
CD207 and IDBG-55659 and ENSG00000116031 and 50489, CD207 and IDBG-631820 and ENSBTAG00000004562 and 511000, Cd207 and IDBG-161509 and ENSMUSG00000034783 and 246278, Plasma membranes, TAP-dependent and biological process this GO :0005537 and mannose binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0030139 and endocytic vesicle and cellular component this GO :0030246 and carbohydrate binding and molecular function this GO :0030669 and clathrin-coated endocytic vesicle membrane and cellular component this GO :0031901 and early endosome membrane and cellular component this GO :0042590 and antigen processing and presentation of exogenous peptide antigen via MHC class I and biological process this GO :0051607 and defense response to virus and biological process, carbohydrate binding, langerin, this GO :0002474 and antigen processing and presentation of peptide antigen via MHC class I and biological process this GO :0002479 and antigen processing and presentation of exogenous peptide antigen via MHC class I, this GO :0005537 : mannose binding, this GO :0005537 : mannose binding and also this GO :0030246 : carbohydrate binding, this GO :0030246 : carbohydrate binding, CD207 molecule |
| Identity: |
17935 |
| Gene: |
CD207 |
More about : CD207 |
| Long gene name: |
CD207 molecule |
| Synonyms gene name: |
CD207 antigen, langerin , langerin CD207 molecule |
| Locus: |
2p13, 3 |
| Discovery year: |
2003-10-02 |
| GenBank acession: |
AJ242859 |
| Entrez gene record: |
50489 |
| Pubmed identfication: |
10661407 9847074 |
| RefSeq identity: |
NM_015717 |
| Classification: |
CD molecules Scavenger receptors C-type lectin domain family |
| Havana BLAST/BLAT: |
OTTHUMG00000153176 |