| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
PXR |
| Specificity: |
This antibody reacts specifically with PXR |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Nucleus |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human PXR |
| Gene ID: |
8856 |
| Swiss Prot: |
O75469 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Activated by naturally occurring steroids, Activated by the antibiotic rifampicin and various plant metabolites, Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes, Response to specific ligands is species-specific, Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, and isoflavones, colupulone, drugs and endogenous compounds, guggulipid, such as hyperforin, such as pregnenolone and progesterone, Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
ONR1 PXR BXR SXR PAR2 |
| Also known as: |
PXR Polyclonal Antibody |
| Other name: |
Anti-PXR Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
PXR |
| Short name: |
Anti-PXR (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-PXR (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
7968 |
| Gene: |
NR1I2 |
More about : NR1I2 |
| Long gene name: |
nuclear receptor subfamily 1 group I member 2 |
| Synonyms gene name: |
group I, member 2 , nuclear receptor subfamily 1 |
| Synonyms name: |
pregnane X receptor orphan nuclear receptor PXR |
| Locus: |
3q13, 33 |
| Discovery year: |
1999-04-23 |
| GenBank acession: |
AF061056 |
| Entrez gene record: |
8856 |
| Pubmed identfication: |
9727070 9770465 |
| Classification: |
Nuclear hormone receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000159400 |