| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
FITC |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
STAT2 |
| Specificity: |
This antibody reacts specifically with STAT2 FITC |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Nucleus, Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human STAT2 |
| Gene ID: |
6773 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Following type I IFN binding to cell surface receptors, ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, Jak kinases (TYK2 and JAK1) are activated, The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, leading to tyrosine phosphorylation of STAT1 and STAT2, that enters the nucleus, which drive the cell in an antiviral state, Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta) |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
494nm/518nm |
| Synonyms: |
STAT113 |
| Also known as: |
STAT2 Polyclonal Antibody FITC |
| Other name: |
Anti-STAT2 Polyclonal FITC |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
Bioss Polyclonal Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, This Bioss Polyclonal Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS |
| Conjugation: |
Anti-FITC Antibody |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
STAT2 |
| Short name: |
Anti-STAT2 (Polyclonal) FITC |
| Technique: |
Fluorescein, Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
FITC |
| Alternative name: |
113kDa (polyclonal), fluorecein, antibody to-signal transducer and activator on transcription 2 |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
113kDa, DNA-templated and biological process this GO :0006355 and regulation of transcription, DNA-templated and biological process this GO :0006357 and regulation of transcription from RNA polymerase II promoter and biological process this GO :0007165 and signal transduction and biological process this GO :0007259 and JAK-STAT cascade and biological process this GO :0016032 and viral process and biological process this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0042802 and identical protein binding and molecular function this GO :0045087 and innate immune response and biological process this GO :0051607 and defense response to virus and biological process this GO :0060337 and type I interferon signaling pathway and biological process this GO :0060338 and regulation of type I interferon-mediated signaling pathway and biological process, ISGF-3 and P113 and STAT113, STAT2 and IDBG-40906 and ENSG00000170581 and 6773, STAT2 and IDBG-635999 and ENSBTAG00000004380 and 511023, Stat2 and IDBG-197036 and ENSMUSG00000040033 and 20847, identical protein binding, nuclei, this GO :0003677 and DNA binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0004871 and signal transducer activity and molecular function this GO :0005509 and calcium ion binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006351 and transcription, this GO :0003677 : DNA binding, this GO :0003677 : DNA binding and also this GO :0003700 : sequence-specific DNA binding transcription factor activity and also this GO :0004871 : signal transducer activity and also this GO :0005509 : calcium ion binding and also this GO :0005515 : protein binding and also this GO :0042802 : identical protein binding, this GO :0003700 : sequence-specific DNA binding transcription factor activity, this GO :0004871 : signal transducer activity, this GO :0005509 : calcium ion binding, this GO :0005515 : protein binding, this GO :0042802 : identical protein binding, signal transducer and activator of transcription 2 |
| Identity: |
11363 |
| Gene: |
STAT2 |
More about : STAT2 |
| Long gene name: |
signal transducer and activator of transcription 2 |
| Synonyms gene name: |
113kD signal transducer and activator of transcription 2, 113kDa , signal transducer and activator of transcription 2 |
| Locus: |
12q13, 2 |
| Discovery year: |
1995-11-08 |
| GenBank acession: |
BC051284 |
| Entrez gene record: |
6773 |
| Pubmed identfication: |
7885841 |
| RefSeq identity: |
NM_005419 |
| Classification: |
SH2 domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000170760 |