| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
SCN2A |
| Specificity: |
This antibody reacts specifically with SCN2A |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human SCN2A |
| Gene ID: |
6326 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
It is heterogeneously expressed in the brain, Several alternatively spliced transcript variants of this gene have been described, They are responsible for the generation and propagation of action potentials in neurons and muscle, This gene encodes one member of the sodium channel alpha subunit gene family, and mutations in this gene have been linked to several seizure disorders, but the full-length nature of some of these variants has not been determined, Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
Nav1, 2 HBSCII HBSCI |
| Also known as: |
SCN2A Polyclonal Antibody |
| Other name: |
Anti-SCN2A Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
SCN2A |
| Short name: |
Anti-SCN2A (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, alpha subunit (polyclonal), classification II, voltage-gated, antibody to-sodium channel |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
BFIC3 and BFIS3 and BFNIS and EIEE11 and HBA and HBSCI and HBSCII and Na(v)1, BT, Plasma membranes, SCN2A and IDBG-74003 and ENSG00000136531 and 6326, Scn2a1 and IDBG-174901 and ENSMUSG00000075318 and 110876, alpha subunit, protein binding, this GO :0001518 and voltage-gated sodium channel complex and cellular component this GO :0005216 and ion channel activity and molecular function this GO :0005248 and voltage-gated sodium channel activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006811 and ion transport and biological process this GO :0006814 and sodium ion transport and biological process this GO :0007399 and nervous system development and biological process this GO :0008627 and intrinsic apoptotic signaling pathway in response to osmotic stress and biological process this GO :0014704 and intercalated disc and cellular component this GO :0016020 and membrane and cellular component this GO :0019228 and neuronal action potential and biological process this GO :0030315 and T-tubule and cellular component this GO :0030424 and axon and cellular component this GO :0031226 and intrinsic component of plasma membrane and cellular component this GO :0033268 and node of Ranvier and cellular component this GO :0033270 and paranode region of axon and cellular component this GO :0034706 and sodium channel complex and cellular component this GO :0034765 and regulation of ion transmembrane transport and biological process this GO :0035725 and sodium ion transmembrane transport and biological process this GO :0042552 and myelination and biological process this GO :0051402 and neuron apoptotic process and biological process this GO :0055085 and transmembrane transport and biological process this GO :0086010 and membrane depolarization during action potential and biological process, this GO :0005216 : ion channel activity, this GO :0005216 : ion channel activity and also this GO :0005248 : voltage-gated sodium channel activity and also this GO :0005515 : protein binding, this GO :0005248 : voltage-gated sodium channel activity, this GO :0005515 : protein binding, type II, voltage-gated, 2 and NAC2 and Nav1, 2 and SCN2A1 and SCN2A2, 99915 and IDBG-641113 and ENSBTAG00000038180 and 539718, sodium channel |
| Identity: |
10588 |
| Gene: |
SCN2A |
More about : SCN2A |
| Long gene name: |
sodium voltage-gated channel alpha subunit 2 |
| Synonyms gene: |
SCN2A1 SCN2A2 |
| Synonyms gene name: |
alpha 1 polypeptide sodium channel, alpha 2 polypeptide sodium channel, alpha subunit sodium channel, sodium channel, type II, type II, type II, type II alpha subunit , voltage gated, voltage-gated, voltage-gated, voltage-gated |
| Locus: |
2q24, 3 |
| Discovery year: |
1992-08-07 |
| GenBank acession: |
AB208888 |
| Entrez gene record: |
6326 |
| Pubmed identfication: |
1317301 16382098 |
| RefSeq identity: |
NM_021007 |
| Classification: |
Sodium voltage-gated channel alpha subunits |
| Havana BLAST/BLAT: |
OTTHUMG00000044172 |