| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
PSAP/PAP |
| Specificity: |
This antibody reacts specifically with PSAP |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Secreted |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human PSAP |
| Gene ID: |
5660 |
| Swiss Prot: |
P07602 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
GM1 gangliosides by beta-galactosidase (EC 3, GPR37 and GPR37L1, Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases, Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3, Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3, Saposins are specific low-molecular mass non-enzymic proteins, rather than by solubilizing the substrate, these effects are mediated by its G-protein-coupled receptors, they participate in the lysosomal degradation of sphingolipids, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling, which takes place by the sequential action of specific hydrolases, 1, 1, 1, 1, 1, 1, 12), 2, 2, 2, 2, 22), 23) and globotriaosylceramide by alpha-galactosidase A (EC 3, 4, 45) and galactosylceramide by beta-galactosylceramidase (EC 3, 46), 6, 8), Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3 |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Also known as: |
PSAP Polyclonal Antibody |
| Other name: |
Anti-PSAP Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
PSAP |
| Short name: |
Anti-PSAP (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-PSAP (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
9498 |
| Gene: |
PSAP |
More about : PSAP |
| Long gene name: |
prosaposin |
| Synonyms gene: |
SAP1 GLBA |
| Synonyms gene name: |
sphingolipid activator protein-1 |
| Synonyms name: |
variant Gaucher disease and variant metachromatic leukodystrophy |
| Locus: |
10q22, 1 |
| Discovery year: |
1986-01-01 |
| GenBank acession: |
BC004275 |
| Entrez gene record: |
5660 |
| Pubmed identfication: |
2717620 |
| RefSeq identity: |
NM_002778 |
| Classification: |
Endogenous ligands |
| Havana BLAST/BLAT: |
OTTHUMG00000018429 |