| Long name: |
ALEXA FLUOR 488 Conjugated, PSAP Polyclonal Antibody |
| Also known as: |
Anti-PSAP/PAP PAb ALEXA FLUOR 488 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
488, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
PSAP/PAP |
| Specificity: |
This is a highly specific antibody against PSAP/PAP |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
144-194/524 |
| Subcellular location: |
Secreted |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human PSAP |
| Gene ID Number: |
5660 |
| Swiss Prot: |
P07602 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
GM1 gangliosides by beta-galactosidase (EC 3, GPR37 and GPR37L1, Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases, Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3, Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3, Saposins are specific low-molecular mass non-enzymic proteins, rather than by solubilizing the substrate, these effects are mediated by its G-protein-coupled receptors, they participate in the lysosomal degradation of sphingolipids, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling, which takes place by the sequential action of specific hydrolases, 1, 1, 1, 1, 1, 1, 12), 2, 2, 2, 2, 22), 23) and globotriaosylceramide by alpha-galactosidase A (EC 3, 4, 45) and galactosylceramide by beta-galactosylceramidase (EC 3, 46), 6, 8), Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3 |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
499nm/519nm |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the PSAP Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
PSAP |
| Short name: |
PSAP Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 488 |
| Alternative name: |
ALEXA FLUOR 488, PSAP (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
9498 |
| Gene: |
PSAP |
More about : PSAP |
| Long gene name: |
prosaposin |
| Synonyms gene: |
SAP1 GLBA |
| Synonyms gene name: |
sphingolipid activator protein-1 |
| Synonyms name: |
variant Gaucher disease and variant metachromatic leukodystrophy |
| Locus: |
10q22, 1 |
| Discovery year: |
1986-01-01 |
| GenBank acession: |
BC004275 |
| Entrez gene record: |
5660 |
| Pubmed identfication: |
2717620 |
| RefSeq identity: |
NM_002778 |
| Classification: |
Endogenous ligands |
| Havana BLAST/BLAT: |
OTTHUMG00000018429 |