| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
MKP-2/DUSP4 |
| Specificity: |
This antibody reacts specifically with MKP-2/DUSP4 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human MKP-2 |
| Gene ID: |
1846 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, ERK2 and JNK, In addition, SAPK/JNK, These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues, They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, This gene product inactivates ERK1, Two alternatively spliced transcript variants, and different modes of inducibility of their expression by extracellular stimuli, and is localized in the nucleus, different tissue distribution and subcellular localization, encoding distinct isoforms, have been observed for this gene, is expressed in a variety of tissues, multiple polyadenylation sites have been reported, p38), which is associated with cellular proliferation and differentiation, DUSP4 is a member of the dual specificity protein phosphatase subfamily |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
HVH2 MKP-2 TYP |
| Also known as: |
MKP-2/DUSP4 Polyclonal Antibody |
| Other name: |
Anti-MKP-2/DUSP4 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
MKP-2/DUSP4 |
| Short name: |
Anti-MKP-2/DUSP4 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-MKP-2/DUSP4 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
3070 |
| Gene: |
DUSP4 |
More about : DUSP4 |
| Long gene name: |
dual specificity phosphatase 4 |
| Synonyms name: |
VH1 homologous phosphatase 2 MAP kinase phosphatase 2 |
| Locus: |
8p12 |
| Discovery year: |
1994-12-14 |
| GenBank acession: |
U21108 |
| Entrez gene record: |
1846 |
| Pubmed identfication: |
7535768 9205128 |
| RefSeq identity: |
NM_001394 |
| Classification: |
MAP kinase phosphatases |
| Havana BLAST/BLAT: |
OTTHUMG00000133395 |