| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Gastrin receptor/GASR/CCKBR |
| Specificity: |
This antibody reacts specifically with Gastrin receptor/CCKBR |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human Gastrin receptor |
| Gene ID: |
887 |
| Swiss Prot: |
P32239 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent mechanism, The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system, analgesia, and neuroleptic activity, arousal, Receptor for gastrin and cholecystokinin |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Also known as: |
Gastrin receptor/CCKBR Antibody |
| Other name: |
Anti-Gastrin receptor/CCKBR |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Description: |
2 or 3 and , However, In this sense, When such chemical-signals couple or bind to a receptor, a change in the electrical-activity of a cell, acetylcholine, am olfactory receptor is a protein-molecule that recognizes and responds to , an acetylcholine-receptor recognizes and responds to its endogenous-ligand, chemokinesor cytokines e, e, sometimes in pharmacology, such as enzymes, the term is also used to include other proteins that are drug-targets, they cause some form of cellular/tissue-response, transporters and ion-channels, The receptors are ligand binding factors of type 1, endogenous-chemical signals, g, g, protein-molecules , that receive chemical-signals from outside a cell |
| Gene target: |
Gastrin receptor/CCKBR |
| Short name: |
Fluor 594, Anti-Gastrin receptor/CCKBR |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Gastrin receptor/cholecystokinin B receptor |
| Alternative to gene target: |
1-phosphatidylinositol-3-kinase regulator activity, CCK-B and CCK2R and GASR, CCKBR and IDBG-28586 and ENSG00000110148 and 887, CCKBR and IDBG-634214 and ENSBTAG00000005236 and 281665, Cckbr and IDBG-204676 and ENSMUSG00000030898 and 12426, Plasma membranes, this GO :0001696 and gastric acid secretion and biological process this GO :0004435 and phosphatidylinositol phospholipase C activity and molecular function this GO :0004930 and G-protein coupled receptor activity and molecular function this GO :0004951 and cholecystokinin receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0007166 and cell surface receptor signaling pathway and biological process this GO :0007186 and G-protein coupled receptor signaling pathway and biological process this GO :0007200 and phospholipase C-activating G-protein coupled receptor signaling pathway and biological process this GO :0007204 and positive regulation of cytosolic calcium ion concentration and biological process this GO :0007586 and digestion and biological process this GO :0007600 and sensory perception and biological process this GO :0007631 and feeding behavior and biological process this GO :0008152 and metabolic process and biological process this GO :0008283 and cell proliferation and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0015054 and gastrin receptor activity and molecular function this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0031741 and type B gastrin/cholecystokinin receptor binding and molecular function this GO :0038188 and cholecystokinin signaling pathway and biological process this GO :0043551 and regulation of phosphatidylinositol 3-kinase activity and biological process this GO :0046935 and 1-phosphatidylinositol-3-kinase regulator activity and molecular function this GO :0048565 and digestive tract development and biological process this GO :0048732 and gland development and biological process, this GO :0004435 : phosphatidylinositol phospholipase C activity, this GO :0004435 : phosphatidylinositol phospholipase C activity and also this GO :0004930 : G-protein coupled receptor activity and also this GO :0004951 : cholecystokinin receptor activity and also this GO :0005515 : protein binding and also this GO :0015054 : gastrin receptor activity and also this GO :0031741 : type B gastrin/cholecystokinin receptor binding and also this GO :0046935 : 1-phosphatidylinositol-3-kinase regulator activity, this GO :0004930 : G-protein coupled receptor activity, this GO :0004951 : cholecystokinin receptor activity, this GO :0005515 : protein binding, this GO :0015054 : gastrin receptor activity, this GO :0031741 : type B gastrin/cholecystokinin receptor binding, this GO :0046935 : 1-phosphatidylinositol-3-kinase regulator activity, cholecystokinin B receptor |
| Identity: |
1571 |
| Gene: |
CCKBR |
More about : CCKBR |
| Long gene name: |
cholecystokinin B receptor |
| Locus: |
11p15, 4 |
| Discovery year: |
1993-07-13 |
| GenBank acession: |
D13305 |
| Entrez gene record: |
887 |
| Pubmed identfication: |
1280419 |
| RefSeq identity: |
NM_176875 |
| Classification: |
Cholecystokinin receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000133380 |