| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
JUP/gamma Catenin |
| Specificity: |
JUP/gamma Catenin, This antibody may have minor cross-reactivity with catenin beta-1 based upon 75% non-contiguous sequence similarity |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Cell membrane |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human Cateninma gamma |
| Gene ID: |
3728 |
| Swiss Prot: |
P14923 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells, Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity), The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue, The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques, Common junctional plaque protein |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
DP3 PDGB PKGB DPIII |
| Also known as: |
JUP/gamma Catenin Polyclonal Antibody |
| Other name: |
Anti-JUP/gamma Catenin Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
JUP/gamma Catenin |
| Short name: |
Anti-JUP/gamma Catenin (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-junction plakoglobin/g Catenin (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
ARVD12 and CTNNG and DP3 and DPIII and PDGB and PKGB, JUP and IDBG-49784 and ENSG00000173801 and 3728, JUP and IDBG-640020 and ENSBTAG00000017685 and 445543, Jup and IDBG-211364 and ENSMUSG00000001552 and 16480, cadherin binding, nuclei, this GO :0000902 and cell morphogenesis and biological process this GO :0002159 and desmosome assembly and biological process this GO :0003136 and negative regulation of heart induction by canonical Wnt receptor signaling pathway and biological process this GO :0003181 and atrioventricular valve morphogenesis and biological process this GO :0003308 and negative regulation of Wnt receptor signaling pathway involved in heart development and biological process this GO :0003713 and transcription coactivator activity and molecular function this GO :0005198 and structural molecule activity and molecular function this GO :0005199 and structural constituent of cell wall and molecular function this GO :0005488 and binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0005856 and cytoskeleton and cellular component this GO :0005882 and intermediate filament and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005911 and cell-cell junction and cellular component this GO :0005913 and cell-cell adherens junction and cellular component this GO :0005915 and zonula adherens and cellular component this GO :0005916 and fascia adherens and cellular component this GO :0007016 and cytoskeletal anchoring at plasma membrane and biological process this GO :0007155 and cell adhesion and biological process this GO :0007369 and gastrulation and biological process this GO :0007398 and ectoderm development and biological process this GO :0007399 and nervous system development and biological process this GO :0009898 and cytoplasmic side of plasma membrane and cellular component this GO :0014704 and intercalated disc and cellular component this GO :0015629 and actin cytoskeleton and cellular component this GO :0016020 and membrane and cellular component this GO :0016323 and basolateral plasma membrane and cellular component this GO :0016327 and apicolateral plasma membrane and cellular component this GO :0016328 and lateral plasma membrane and cellular component this GO :0016331 and morphogenesis of embryonic epithelium and biological process this GO :0016337 and single organismal cell-cell adhesion and biological process this GO :0016342 and catenin complex and cellular component this GO :0016477 and cell migration and biological process this GO :0019901 and protein kinase binding and molecular function this GO :0019903 and protein phosphatase binding and molecular function this GO :0030018 and Z disc and cellular component this GO :0030057 and desmosome and cellular component this GO :0032993 and protein-DNA complex and cellular component this GO :0034329 and cell junction assembly and biological process this GO :0034332 and adherens junction organization and biological process this GO :0042127 and regulation of cell proliferation and biological process this GO :0042307 and positive regulation of protein import into nucleus and biological process this GO :0042803 and protein homodimerization activity and molecular function this GO :0043588 and skin development and biological process this GO :0045216 and cell-cell junction organization and biological process this GO :0045294 and alpha-catenin binding and molecular function this GO :0045296 and cadherin binding and molecular function this GO :0048599 and oocyte development and biological process this GO :0050982 and detection of mechanical stimulus and biological process this GO :0051091 and positive regulation of sequence-specific DNA binding transcription factor activity and biological process this GO :0051291 and protein heterooli this GO merization and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0071603 and endothelial cell-cell adhesion and biological process this GO :0071665 and gamma-catenin-TCF7L2 complex and cellular component this GO :0071681 and cellular response to indole-3-methanol and biological process this GO :0086005 and ventricular cardiac muscle cell action potential and biological process this GO :0086069 and bundle of His cell to Purkinje myocyte communication and biological process this GO :0086091 and regulation of heart rate by cardiac conduction and biological process this GO :0090002 and establishment of protein localization to plasma membrane and biological process this GO :0090263 and positive regulation of canonical Wnt signaling pathway and biological process, this GO :0003713 : transcription coactivator activity, this GO :0003713 : transcription coactivator activity and also this GO :0005198 : structural molecule activity and also this GO :0005199 : structural constituent of cell wall and also this GO :0005488 : binding and also this GO :0005515 : protein binding and also this GO :0019901 : protein kinase binding and also this GO :0019903 : protein phosphatase binding and also this GO :0042803 : protein homodimerization activity and also this GO :0045294 : alpha-catenin binding and also this GO :0045296 : cadherin binding, this GO :0005198 : structural molecule activity, this GO :0005199 : structural constituent of cell wall, this GO :0005488 : binding, this GO :0005515 : protein binding, this GO :0019901 : protein kinase binding, this GO :0019903 : protein phosphatase binding, this GO :0042803 : protein homodimerization activity, this GO :0045294 : alpha-catenin binding, this GO :0045296 : cadherin binding, junction plakoglobin |
| Identity: |
6207 |
| Gene: |
JUP |
More about : JUP |
| Long gene name: |
junction plakoglobin |
| Synonyms gene: |
CTNNG |
| Synonyms gene name: |
catenin (cadherin-associated protein), gamma 80kDa |
| Locus: |
17q21, 2 |
| Discovery year: |
1991-03-04 |
| GenBank acession: |
AF233882 |
| Entrez gene record: |
3728 |
| Pubmed identfication: |
1889810 7604000 |
| Classification: |
Armadillo repeat containing |
| Havana BLAST/BLAT: |
OTTHUMG00000133494 |
| Locus Specific Databases: |
Gene Connection for the Heart, Naxos disease database ARVD/C Genetic Variants Database LRG_401 |