| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
CXCR2/CD182 |
| Specificity: |
This antibody reacts specifically with CXCR2/CD182 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human CXCR2 |
| Gene ID: |
3579 |
| Swiss Prot: |
P25025 |
| Applications: |
IF(ICC), IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(ICC)(1:50-200), IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Also binds with high affinity to CXCL3, Binding of IL-8 to the receptor causes activation of neutrophils, Binds to IL-8 with high affinity, GRO/MGSA and NAP-2, This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system, Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
CMKAR2 CD182 |
| Also known as: |
CXCR2/CD182 Polyclonal Antibody |
| Other name: |
Anti-CXCR2/CD182 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
CXCR2/CD182 |
| Short name: |
Anti-CXCR2/CD182 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-chemokine (C-X-C motif) receptor 2/CD182 (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
CD182 and CDw128b and CMKAR2 and IL8R2 and IL8RA and IL8RB, CXCR2 and IDBG-80804 and ENSG00000180871 and 3579, Cell surfaces, Cxcr2 and IDBG-166395 and ENSMUSG00000026180 and 12765, interleukin-8 binding, this GO :0002407 and dendritic cell chemotaxis and biological process this GO :0004871 and signal transducer activity and molecular function this GO :0004918 and interleukin-8 receptor activity and molecular function this GO :0004930 and G-protein coupled receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005622 and intracellular and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006935 and chemotaxis and biological process this GO :0006954 and inflammatory response and biological process this GO :0006968 and cellular defense response and biological process this GO :0007165 and signal transduction and biological process this GO :0007166 and cell surface receptor signaling pathway and biological process this GO :0007186 and G-protein coupled receptor signaling pathway and biological process this GO :0007200 and phospholipase C-activating G-protein coupled receptor signaling pathway and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0009986 and cell surface and cellular component this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016494 and C-X-C chemokine receptor activity and molecular function this GO :0019959 and interleukin-8 binding and molecular function this GO :0030593 and neutrophil chemotaxis and biological process this GO :0031623 and receptor internalization and biological process this GO :0038112 and interleukin-8-mediated signaling pathway and biological process this GO :0042119 and neutrophil activation and biological process this GO :0042629 and mast cell granule and cellular component this GO :0045087 and innate immune response and biological process this GO :0070098 and chemokine-mediated signaling pathway and biological process, this GO :0004871 : signal transducer activity, this GO :0004871 : signal transducer activity and also this GO :0004918 : interleukin-8 receptor activity and also this GO :0004930 : G-protein coupled receptor activity and also this GO :0005515 : protein binding and also this GO :0016494 : C-X-C chemokine receptor activity and also this GO :0019959 : interleukin-8 binding, this GO :0004918 : interleukin-8 receptor activity, this GO :0004930 : G-protein coupled receptor activity, this GO :0005515 : protein binding, this GO :0016494 : C-X-C chemokine receptor activity, this GO :0019959 : interleukin-8 binding, chemokine (C-X-C motif) receptor 2 |
| Identity: |
6027 |
| Gene: |
CXCR2 |
More about : CXCR2 |
| Long gene name: |
C-X-C motif chemokine receptor 2 |
| Synonyms gene: |
IL8RB |
| Synonyms gene name: |
beta chemokine (C-X-C motif) receptor 2 , interleukin 8 receptor |
| Locus: |
2q35 |
| Discovery year: |
1991-08-19 |
| GenBank acession: |
U11869 |
| Entrez gene record: |
3579 |
| Pubmed identfication: |
1427896 |
| RefSeq identity: |
NM_001557 |
| Classification: |
CD molecules C-X-C motif chemokine receptors Interleukin receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000133107 |