| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
CD46/MCP |
| Specificity: |
This antibody reacts specifically with CD46/MCP |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic peptide derived from Mouse CD46 |
| Gene ID: |
4179 |
| Swiss Prot: |
P15529 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46, Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells, May be involved in the fusion of the spermatozoa with the oocyte during fertilization, T-regulatory 1 cells suppress immune responses by secreting interleukin-10, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue, and therefore are thought to prevent autoimmunity, Acts as a cofactor for complement factor I |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
TRA2, 10 MGC26544 TLX |
| Also known as: |
CD46/MCP Polyclonal Antibody |
| Other name: |
Anti-CD46/MCP Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
CD46/MCP |
| Short name: |
Anti-CD46/MCP (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, complement regulatory protein/MCP (polyclonal), antibody to-CD46 molecule |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
AHUS2 and MCP and MIC10 and TLX and TRA2, BT, CD46 and IDBG-106372 and ENSG00000117335 and 4179, Cd46 and IDBG-209330 and ENSMUSG00000016493 and 17221, Cell surfaces, cadherin binding, classical pathway and biological process this GO :0007338 and single fertilization and biological process this GO :0008593 and regulation of Notch signaling pathway and biological process this GO :0009986 and cell surface and cellular component this GO :0010628 and positive regulation of gene expression and biological process this GO :0010629 and negative regulation of gene expression and biological process this GO :0016032 and viral process and biological process this GO :0030449 and regulation of complement activation and biological process this GO :0032613 and interleukin-10 production and biological process this GO :0032733 and positive regulation of interleukin-10 production and biological process this GO :0035581 and sequestering of extracellular ligand from receptor and biological process this GO :0042102 and positive regulation of T cell proliferation and biological process this GO :0043382 and positive regulation of memory T cell differentiation and biological process this GO :0045087 and innate immune response and biological process this GO :0045296 and cadherin binding and molecular function this GO :0045591 and positive regulation of regulatory T cell differentiation and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0071636 and positive regulation of transforming growth factor beta production and biological process, complement regulatory protein, this GO :0002079 and inner acrosomal membrane and cellular component this GO :0002250 and adaptive immune response and biological process this GO :0002456 and T cell mediated immunity and biological process this GO :0004872 and receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006958 and complement activation, this GO :0004872 : receptor activity, this GO :0004872 : receptor activity and also this GO :0005515 : protein binding and also this GO :0045296 : cadherin binding, this GO :0005515 : protein binding, this GO :0045296 : cadherin binding, 10, 68611 and IDBG-638462 and ENSBTAG00000005397 and 280851, CD46 molecule |
| Identity: |
6953 |
| Gene: |
CD46 |
More about : CD46 |
| Long gene name: |
CD46 molecule |
| Synonyms gene: |
MIC10 MCP |
| Synonyms gene name: |
antigen identified by monoclonal antibody TRA-2-10 membrane cofactor protein (CD46, complement regulatory protein , complement regulatory protein CD46 molecule, trophoblast-lymphocyte cross-reactive antigen) CD46 antigen |
| Locus: |
1q32, 2 |
| Discovery year: |
1988-08-31 |
| GenBank acession: |
BC030594 |
| Entrez gene record: |
4179 |
| Pubmed identfication: |
7929741 |
| RefSeq identity: |
NM_172361 |
| Classification: |
Sushi domain containing Complement system CD molecules |
| Havana BLAST/BLAT: |
OTTHUMG00000036397 |
| Locus Specific Databases: |
LRG_155 |