| Long name: |
ALEXA FLUOR 488 Conjugated, CD46/MCP Polyclonal Antibody |
| Also known as: |
Anti-CD46/MCP PAb ALEXA FLUOR 488 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
488, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
CD46/MCP |
| Specificity: |
This is a highly specific antibody against CD46/MCP |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
250-300/365 |
| Subcellular location: |
Cytoplasm |
| Source: |
KLH conjugated synthetic peptide derived from Mouse CD46 |
| Gene ID Number: |
4179 |
| Swiss Prot: |
P15529 |
| Tested applications: |
IF(IHC-P), FCM |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), FCM(1:20-100) |
| Crossreactivity: |
Mouse |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46, Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells, May be involved in the fusion of the spermatozoa with the oocyte during fertilization, T-regulatory 1 cells suppress immune responses by secreting interleukin-10, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue, and therefore are thought to prevent autoimmunity, Acts as a cofactor for complement factor I |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
499nm/519nm |
| Synonyms: |
TRA2, 10 MGC26544 TLX |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the CD46/MCP Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
CD46/MCP |
| Short name: |
CD46/MCP Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 488 |
| Alternative name: |
ALEXA FLUOR 488, complement regulatory protein/MCP (Antibody to), CD46 molecule |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
AHUS2 and MCP and MIC10 and TLX and TRA2, BT, CD46 and IDBG-106372 and ENSG00000117335 and 4179, Cd46 and IDBG-209330 and ENSMUSG00000016493 and 17221, Cell surfaces, cadherin binding, classical pathway and biological process this GO :0007338 and single fertilization and biological process this GO :0008593 and regulation of Notch signaling pathway and biological process this GO :0009986 and cell surface and cellular component this GO :0010628 and positive regulation of gene expression and biological process this GO :0010629 and negative regulation of gene expression and biological process this GO :0016032 and viral process and biological process this GO :0030449 and regulation of complement activation and biological process this GO :0032613 and interleukin-10 production and biological process this GO :0032733 and positive regulation of interleukin-10 production and biological process this GO :0035581 and sequestering of extracellular ligand from receptor and biological process this GO :0042102 and positive regulation of T cell proliferation and biological process this GO :0043382 and positive regulation of memory T cell differentiation and biological process this GO :0045087 and innate immune response and biological process this GO :0045296 and cadherin binding and molecular function this GO :0045591 and positive regulation of regulatory T cell differentiation and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0071636 and positive regulation of transforming growth factor beta production and biological process, complement regulatory protein, this GO :0002079 and inner acrosomal membrane and cellular component this GO :0002250 and adaptive immune response and biological process this GO :0002456 and T cell mediated immunity and biological process this GO :0004872 and receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006958 and complement activation, this GO :0004872 : receptor activity, this GO :0004872 : receptor activity and also this GO :0005515 : protein binding and also this GO :0045296 : cadherin binding, this GO :0005515 : protein binding, this GO :0045296 : cadherin binding, 10, 68611 and IDBG-638462 and ENSBTAG00000005397 and 280851, CD46 molecule |
| Identity: |
6953 |
| Gene: |
CD46 |
More about : CD46 |
| Long gene name: |
CD46 molecule |
| Synonyms gene: |
MIC10 MCP |
| Synonyms gene name: |
antigen identified by monoclonal antibody TRA-2-10 membrane cofactor protein (CD46, complement regulatory protein , complement regulatory protein CD46 molecule, trophoblast-lymphocyte cross-reactive antigen) CD46 antigen |
| Locus: |
1q32, 2 |
| Discovery year: |
1988-08-31 |
| GenBank acession: |
BC030594 |
| Entrez gene record: |
4179 |
| Pubmed identfication: |
7929741 |
| RefSeq identity: |
NM_172361 |
| Classification: |
Sushi domain containing Complement system CD molecules |
| Havana BLAST/BLAT: |
OTTHUMG00000036397 |
| Locus Specific Databases: |
LRG_155 |