| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
NeuroD1 |
| Specificity: |
This antibody reacts specifically with NeuroD1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Nucleus, Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human NeuroD1 |
| Gene ID: |
4760 |
| Swiss Prot: |
Q13562 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Also required for dendrite morphogenesis and maintenance in the cerebellar cortex, Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity), Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A, Contributes to the regulation of several cell differentiation pathways, Together with PAX6 or SIX3, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, inner ear sensory neurons, is required for the regulation of amacrine cell fate specification, like those that promote the formation of early retinal ganglion cells, Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3' |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
BETA2 BHF-1 NeuroD bHLHa3 MODY6 |
| Also known as: |
NeuroD1 Polyclonal Antibody |
| Other name: |
Anti-NeuroD1 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
NeuroD1 |
| Short name: |
Anti-NeuroD1 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-neuronal differentiation 1 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
7762 |
| Gene: |
NEUROD1 |
More about : NEUROD1 |
| Long gene name: |
neuronal differentiation 1 |
| Synonyms gene: |
NEUROD |
| Synonyms gene name: |
neurogenic differentiation 1 |
| Synonyms name: |
beta-cell E-box transactivator 2 neurogenic helix-loop-helix protein NEUROD |
| Locus: |
2q31, 3 |
| Discovery year: |
1996-03-12 |
| GenBank acession: |
U50823 |
| Entrez gene record: |
4760 |
| Pubmed identfication: |
7754368 8786144 |
| RefSeq identity: |
NM_002500 |
| Classification: |
Basic helix-loop-helix proteins |
| Havana BLAST/BLAT: |
OTTHUMG00000132583 |