| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
HSP75/TRAP1 |
| Specificity: |
This antibody reacts specifically with HSP75/TRAP1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Mitochondrion |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human HSP75 |
| Gene ID: |
10131 |
| Swiss Prot: |
Q12931 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Involved in maintaining mitochondrial function and polarization, Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis, The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA, most likely through stabilization of mitochondrial complex I, Chaperone that expresses an ATPase activity |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
HSP75 HSP90L |
| Also known as: |
HSP75/TRAP1 Polyclonal Antibody |
| Other name: |
Anti-HSP75/TRAP1 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
HSP75/TRAP1 |
| Short name: |
Anti-HSP75/TRAP1 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-HSP75/tumor necrosis factor receptor-associated protein 1 (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
HSP 75 and HSP75 and HSP90L and TRAP-1, TRAP1 and IDBG-12290 and ENSG00000126602 and 10131, TRAP1 and IDBG-636097 and ENSBTAG00000020109 and 514472, Trap1 and IDBG-129450 and ENSMUSG00000005981 and 68015, nuclei, this GO :0005164 and tumor necrosis factor receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005743 and mitochondrial inner membrane and cellular component this GO :0005758 and mitochondrial intermembrane space and cellular component this GO :0005759 and mitochondrial matrix and cellular component this GO :0006457 and protein folding and biological process this GO :0006950 and response to stress and biological process this GO :0016020 and membrane and cellular component this GO :0044822 and poly(A) RNA binding and molecular function this GO :0051082 and unfolded protein binding and molecular function this GO :0070062 and extracellular vesicular exosome and cellular component this GO :1901856 and negative regulation of cellular respiration and biological process this GO :1902176 and negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway and biological process, this GO :0005164 : tumor necrosis factor receptor binding, this GO :0005164 : tumor necrosis factor receptor binding and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0044822 : poly(A) RNA binding and also this GO :0051082 : unfolded protein binding, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0044822 : poly(A) RNA binding, this GO :0051082 : unfolded protein binding, unfolded protein binding, 101929751, TNF receptor-associated protein 1 |
| Identity: |
16264 |
| Gene: |
TRAP1 |
More about : TRAP1 |
| Long gene name: |
TNF receptor associated protein 1 |
| Synonyms gene name: |
TNF receptor-associated protein 1 |
| Locus: |
16p13, 3 |
| Discovery year: |
2004-07-02 |
| GenBank acession: |
AF154108 |
| Entrez gene record: |
10131 |
| Pubmed identfication: |
10652318 7876093 |
| RefSeq identity: |
NM_016292 |
| Classification: |
Heat shock 90kDa proteins |
| Havana BLAST/BLAT: |
OTTHUMG00000129427 |