| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
IGFBP3 |
| Specificity: |
This antibody reacts specifically with IGFBP3 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Secreted |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human IGFBP3 |
| Gene ID: |
3486 |
| Swiss Prot: |
P17936 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R, They alter the interaction of IGFs with their cell surface receptors, IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
IBP3 BP-53 |
| Also known as: |
IGFBP3 Polyclonal Antibody |
| Other name: |
Anti-IGFBP3 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
IGFBP3 |
| Short name: |
Anti-IGFBP3 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-insulin-like growth factor binding protein 3 (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
BP-53 and IBP3, IGFBP3 and IDBG-15809 and ENSG00000146674 and 3486, IGFBP3 and IDBG-633994 and ENSBTAG00000003994 and 282261, Igfbp3 and IDBG-148893 and ENSMUSG00000020427 and 16009, metal ion binding, nuclei, this GO :0001558 and regulation of cell growth and biological process this GO :0001649 and osteoblast differentiation and biological process this GO :0001933 and negative regulation of protein phosphorylation and biological process this GO :0001968 and fibronectin binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005520 and insulin-like growth factor binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005615 and extracellular space and cellular component this GO :0005634 and nucleus and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006915 and apoptotic process and biological process this GO :0008160 and protein tyrosine phosphatase activator activity and molecular function this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0009968 and negative regulation of signal transduction and biological process this GO :0010906 and regulation of glucose metabolic process and biological process this GO :0014912 and negative regulation of smooth muscle cell migration and biological process this GO :0016942 and insulin-like growth factor binding protein complex and cellular component this GO :0031994 and insulin-like growth factor I binding and molecular function this GO :0040008 and regulation of growth and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043085 and positive regulation of catalytic activity and biological process this GO :0043410 and positive regulation of MAPK cascade and biological process this GO :0043568 and positive regulation of insulin-like growth factor receptor signaling pathway and biological process this GO :0044267 and cellular protein metabolic process and biological process this GO :0044342 and type B pancreatic cell proliferation and biological process this GO :0045663 and positive regulation of myoblast differentiation and biological process this GO :0046872 and metal ion binding and molecular function this GO :0048662 and negative regulation of smooth muscle cell proliferation and biological process this GO :0070062 and extracellular vesicular exosome and cellular component, this GO :0001968 : fibronectin binding, this GO :0001968 : fibronectin binding and also this GO :0005515 : protein binding and also this GO :0005520 : insulin-like growth factor binding and also this GO :0008160 : protein tyrosine phosphatase activator activity and also this GO :0031994 : insulin-like growth factor I binding and also this GO :0046872 : metal ion binding, this GO :0005515 : protein binding, this GO :0005520 : insulin-like growth factor binding, this GO :0008160 : protein tyrosine phosphatase activator activity, this GO :0031994 : insulin-like growth factor I binding, this GO :0046872 : metal ion binding, insulin-like growth factor binding protein 3 |
| Identity: |
5472 |
| Gene: |
IGFBP3 |
More about : IGFBP3 |
| Long gene name: |
insulin like growth factor binding protein 3 |
| Synonyms gene name: |
insulin-like growth factor binding protein 3 |
| Synonyms name: |
growth hormone-dependent binding protein acid stable subunit of the 140 K IGF complex binding protein 53 binding protein 29 IGF-binding protein 3 |
| Locus: |
7p12, 3 |
| Discovery year: |
1991-07-09 |
| Entrez gene record: |
3486 |
| Pubmed identfication: |
1695633 |
| RefSeq identity: |
NM_001013398 |
| Classification: |
Insulin like growth factor binding proteins |
| Havana BLAST/BLAT: |
OTTHUMG00000023769 |
| Locus Specific Databases: |
LRG_68 |