| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
ERCC6 |
| Specificity: |
This antibody reacts specifically with ERCC6 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Nucleus |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human ERCC6 |
| Gene ID: |
2074 |
| Swiss Prot: |
Q03468 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
It is required for transcription-coupled repair complex formation, It recruits the CSA complex (DCX(ERCC8) complex), Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, nucleotide excision repair proteins and EP300 to the at sites of RNA polymerase II-blocking lesions, thereby modifying the interface between stalled RNA polymerase II and DNA, Essential factor involved in transcription-coupled nucleotide excision repair which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
CSB RAD26 ARMD5 |
| Also known as: |
ERCC6 Polyclonal Antibody |
| Other name: |
Anti-ERCC6 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
ERCC6 |
| Short name: |
Anti-ERCC6 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, complementation family 6 (polyclonal), antibody to-excision repair cross-complementing rodent repair deficiency |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
ARMD5 and CKN2 and COFS and COFS1 and CSB and RAD26 and UVSS1, ERCC6 and IDBG-304121 and ENSG00000225830 and 2074, ERCC6 and IDBG-631777 and ENSBTAG00000032527 and 522908, Ercc6 and IDBG-147857 and ENSMUSG00000054051 and 319955, complementation group 6, elongation and biological process this GO :0032786 and positive regulation of DNA-templated transcription, elongation and biological process this GO :0035264 and multicellular organism growth and biological process this GO :0045494 and photoreceptor cell maintenance and biological process this GO :0047485 and protein N-terminus binding and molecular function, nuclei, protein N-terminus binding, this GO :0000303 and response to superoxide and biological process this GO :0003677 and DNA binding and molecular function this GO :0003682 and chromatin binding and molecular function this GO :0004386 and helicase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005730 and nucleolus and cellular component this GO :0006200 and ATP catabolic process and biological process this GO :0006281 and DNA repair and biological process this GO :0006283 and transcription-coupled nucleotide-excision repair and biological process this GO :0006284 and base-excision repair and biological process this GO :0006289 and nucleotide-excision repair and biological process this GO :0006290 and pyrimidine dimer repair and biological process this GO :0006362 and transcription elongation from RNA polymerase I promoter and biological process this GO :0006366 and transcription from RNA polymerase II promoter and biological process this GO :0006974 and cellular response to DNA damage stimulus and biological process this GO :0006979 and response to oxidative stress and biological process this GO :0007256 and activation of JNKK activity and biological process this GO :0007257 and activation of JUN kinase activity and biological process this GO :0008022 and protein C-terminus binding and molecular function this GO :0008023 and transcription elongation factor complex and cellular component this GO :0008094 and DNA-dependent ATPase activity and molecular function this GO :0008630 and intrinsic apoptotic signaling pathway in response to DNA damage and biological process this GO :0009411 and response to UV and biological process this GO :0009636 and response to toxic substance and biological process this GO :0010165 and response to X-ray and biological process this GO :0010224 and response to UV-B and biological process this GO :0010332 and response to gamma radiation and biological process this GO :0032403 and protein complex binding and molecular function this GO :0032784 and regulation of DNA-templated transcription, this GO :0003677 : DNA binding, this GO :0003677 : DNA binding and also this GO :0003682 : chromatin binding and also this GO :0004386 : helicase activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0008022 : protein C-terminus binding and also this GO :0008094 : DNA-dependent ATPase activity and also this GO :0032403 : protein complex binding and also this GO :0047485 : protein N-terminus binding, this GO :0003682 : chromatin binding, this GO :0004386 : helicase activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0008022 : protein C-terminus binding, this GO :0008094 : DNA-dependent ATPase activity, this GO :0032403 : protein complex binding, this GO :0047485 : protein N-terminus binding, excision repair cross-complementing rodent repair deficiency |
| Identity: |
3438 |
| Gene: |
ERCC6 |
More about : ERCC6 |
| Long gene name: |
ERCC excision repair 6, chromatin remodeling factor |
| Synonyms gene: |
CKN2 |
| Synonyms gene name: |
complementation group 6 excision repair cross-complementation group 6 , excision repair cross-complementing rodent repair deficiency |
| Synonyms name: |
Cockayne syndrome B protein |
| Locus: |
10q11, 23 |
| Discovery year: |
1989-06-30 |
| GenBank acession: |
L04791 |
| Entrez gene record: |
2074 |
| Pubmed identfication: |
1339317 19179336 |
| RefSeq identity: |
NM_000124 |
| Classification: |
ERCC excision repair associated |
| Havana BLAST/BLAT: |
OTTHUMG00000018195 |
| Locus Specific Databases: |
LRG_465 |