| Long name: |
FITC Conjugated, ERCC6 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Anti-FITC Antibody |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
ERCC6 |
| Specificity: |
This is a highly specific antibody against ERCC6 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
240-275/1493 |
| Subcellular location: |
Nucleus |
| Source: |
KLH conjugated synthetic peptide derived from human ERCC6 |
| Gene ID number: |
2074 |
| Swiss Prot: |
Q03468 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
It is required for transcription-coupled repair complex formation, It recruits the CSA complex (DCX(ERCC8) complex), Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, nucleotide excision repair proteins and EP300 to the at sites of RNA polymerase II-blocking lesions, thereby modifying the interface between stalled RNA polymerase II and DNA, Essential factor involved in transcription-coupled nucleotide excision repair which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
494nm/518nm |
| Synonyms: |
CSB RAD26 ARMD5 |
| Properties: |
Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
ERCC6 Conjugated |
| Short name: |
FITC Conjugated, ERCC6 Antibody |
| Technique: |
Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
FITC |
| Alternative name: |
complementation family 6 (Antibody to), fluorecein coupled, excision repair cross-complementing rodent repair deficiency |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
ARMD5 and CKN2 and COFS and COFS1 and CSB and RAD26 and UVSS1, ERCC6 and IDBG-304121 and ENSG00000225830 and 2074, ERCC6 and IDBG-631777 and ENSBTAG00000032527 and 522908, Ercc6 and IDBG-147857 and ENSMUSG00000054051 and 319955, complementation group 6, elongation and biological process this GO :0032786 and positive regulation of DNA-templated transcription, elongation and biological process this GO :0035264 and multicellular organism growth and biological process this GO :0045494 and photoreceptor cell maintenance and biological process this GO :0047485 and protein N-terminus binding and molecular function, nuclei, protein N-terminus binding, this GO :0000303 and response to superoxide and biological process this GO :0003677 and DNA binding and molecular function this GO :0003682 and chromatin binding and molecular function this GO :0004386 and helicase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005730 and nucleolus and cellular component this GO :0006200 and ATP catabolic process and biological process this GO :0006281 and DNA repair and biological process this GO :0006283 and transcription-coupled nucleotide-excision repair and biological process this GO :0006284 and base-excision repair and biological process this GO :0006289 and nucleotide-excision repair and biological process this GO :0006290 and pyrimidine dimer repair and biological process this GO :0006362 and transcription elongation from RNA polymerase I promoter and biological process this GO :0006366 and transcription from RNA polymerase II promoter and biological process this GO :0006974 and cellular response to DNA damage stimulus and biological process this GO :0006979 and response to oxidative stress and biological process this GO :0007256 and activation of JNKK activity and biological process this GO :0007257 and activation of JUN kinase activity and biological process this GO :0008022 and protein C-terminus binding and molecular function this GO :0008023 and transcription elongation factor complex and cellular component this GO :0008094 and DNA-dependent ATPase activity and molecular function this GO :0008630 and intrinsic apoptotic signaling pathway in response to DNA damage and biological process this GO :0009411 and response to UV and biological process this GO :0009636 and response to toxic substance and biological process this GO :0010165 and response to X-ray and biological process this GO :0010224 and response to UV-B and biological process this GO :0010332 and response to gamma radiation and biological process this GO :0032403 and protein complex binding and molecular function this GO :0032784 and regulation of DNA-templated transcription, this GO :0003677 : DNA binding, this GO :0003677 : DNA binding and also this GO :0003682 : chromatin binding and also this GO :0004386 : helicase activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0008022 : protein C-terminus binding and also this GO :0008094 : DNA-dependent ATPase activity and also this GO :0032403 : protein complex binding and also this GO :0047485 : protein N-terminus binding, this GO :0003682 : chromatin binding, this GO :0004386 : helicase activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0008022 : protein C-terminus binding, this GO :0008094 : DNA-dependent ATPase activity, this GO :0032403 : protein complex binding, this GO :0047485 : protein N-terminus binding, excision repair cross-complementing rodent repair deficiency |
| Identity: |
3438 |
| Gene: |
ERCC6 |
More about : ERCC6 |
| Long gene name: |
ERCC excision repair 6, chromatin remodeling factor |
| Synonyms gene: |
CKN2 |
| Synonyms gene name: |
complementation group 6 excision repair cross-complementation group 6 , excision repair cross-complementing rodent repair deficiency |
| Synonyms name: |
Cockayne syndrome B protein |
| Locus: |
10q11, 23 |
| Discovery year: |
1989-06-30 |
| GenBank acession: |
L04791 |
| Entrez gene record: |
2074 |
| Pubmed identfication: |
1339317 19179336 |
| RefSeq identity: |
NM_000124 |
| Classification: |
ERCC excision repair associated |
| Havana BLAST/BLAT: |
OTTHUMG00000018195 |
| Locus Specific Databases: |
LRG_465 |