| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
GPR124 |
| Specificity: |
This antibody reacts specifically with GPR124/TEM5 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human G protein coupled receptor 124 |
| Gene ID: |
25960 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
TEM5 (G-protein coupled receptor 124) and TEM7 (plexin domain containing 1), TEM5 and TEM7 may be suitable targets for the development of antiangiogenic therapies, TEM5 expression is elevated during tumor angiogenesis and neoangiogenesis, TEM5 is a seven-pass transmembrane receptor, TEM7 and TEM8 span the membrane once, TEM7 is highly expressed in tumor endothelium and neurons, TEMs are associated with the cell surface membrane at low levels in normal human and mouse tissues, Therefore, These include TEM1 (endosialin), whereas TEM1, Tumor endothelial markers (TEMs) are abundantly expressed in the blood vessels of human solid tumors during angiogenesis and neoangiogensis |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
TEM5 DKFZp434C211 DKFZp434J0911 KIAA1531 FLJ14390 |
| Also known as: |
GPR124/TEM5 Polyclonal Antibody |
| Other name: |
Anti-GPR124/TEM5 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
GPR124/TEM5 |
| Short name: |
Anti-GPR124/TEM5 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-GPR124/TEM5 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
17849 |
| Gene: |
ADGRA2 |
More about : ADGRA2 |
| Long gene name: |
adhesion G protein-coupled receptor A2 |
| Synonyms gene: |
GPR124 |
| Synonyms gene name: |
G protein-coupled receptor 124 |
| Synonyms name: |
tumor endothelial marker 5 |
| Locus: |
8p11, 23 |
| Discovery year: |
2003-02-25 |
| GenBank acession: |
AB040964 |
| Entrez gene record: |
25960 |
| Pubmed identfication: |
11559528 12565841 25713288 |
| Classification: |
Immunoglobulin like domain containing Adhesion G protein-coupled receptors, subfamily A |
| Havana BLAST/BLAT: |
OTTHUMG00000156182 |