| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
FCGRT/FcRn |
| Specificity: |
This antibody reacts specifically with FCGRT/FcRn |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human FCGRT/FcRn |
| Gene ID: |
2217 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Brambell receptor, FcRN localizes in endosomes of vascular endothelial cells and selectively recycles IgG to the cell surface, FcRn &, FcRn (also designated FCGRT, FcRn heavy chain shows approximately 35% amino acid identity to an MHC class I molecule, IgG Gc receptor and neonatal Fc-receptor) is comprised of a heavy chain and â, This protection mechanism is a major constituent for ensuring IgG are the longest lived of all plasma proteins, chain, thereby helping newborn animals to acquire passive immunity, thus protecting IgG from lysosomal catabolism, #229, &circ, «, -2-Microglobulin, FcRN present in the intestinal epithelium of neonatal mice and rats mediates the selective uptake of immunoglobulin G (IgG) in mothers' milk |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
FCRN alpha-chain |
| Also known as: |
FCGRT/FcRn Polyclonal Antibody |
| Other name: |
Anti-FCGRT/FcRn Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
FCGRT/FcRn |
| Short name: |
Anti-FCGRT/FcRn (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, alpha/FcRn (polyclonal), receptor, transporter, antibody to-fragment c fragment on Immunoglobulin G |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
FCGRT and IDBG-63001 and ENSG00000104870 and 2217, FCGRT and IDBG-640575 and ENSBTAG00000013926 and 338062, Fcgrt and IDBG-181534 and ENSMUSG00000003420 and 14132, Plasma membranes, alpha, alpha-chain and FCRN, beta-2-microglobulin binding, receptor, this GO :0002416 and IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor and biological process this GO :0005515 and protein binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0006955 and immune response and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0019864 and IgG binding and molecular function this GO :0019882 and antigen processing and presentation and biological process this GO :0030881 and beta-2-microglobulin binding and molecular function this GO :0038094 and Fc-gamma receptor signaling pathway and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding and also this GO :0019864 : IgG binding and also this GO :0030881 : beta-2-microglobulin binding, this GO :0019864 : IgG binding, this GO :0030881 : beta-2-microglobulin binding, transporter, Fc fragment of IgG |
| Identity: |
3621 |
| Gene: |
FCGRT |
More about : FCGRT |
| Long gene name: |
Fc fragment of IgG receptor and transporter |
| Synonyms gene name: |
Fc fragment of IgG, alpha , receptor, transporter |
| Synonyms name: |
heavy chain of the major histocompatibility complex class I-like Fc receptor transmembrane alpha chain of the neonatal receptor |
| Locus: |
19q13, 33 |
| Discovery year: |
1995-08-23 |
| GenBank acession: |
U12255 |
| Entrez gene record: |
2217 |
| Pubmed identfication: |
7964511 8646894 |
| Classification: |
C1-set domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000183155 |