| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
TMEM16C/Anoctamin 3 |
| Specificity: |
This antibody reacts specifically with TMEM16C/Anoctamin 3 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human TMEM16C/Anoctamin 3 |
| Gene ID: |
63982 |
| Applications: |
IF(IHC-P), FCM |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200), FCM(1:20-100) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Atm mutation leads to the disorder known as ataxia-telangiectasia, Jacobsen syndrome, Jervell and Lange-Nielsen syndrome, Niemann-Pick disease, The blood disorders Sickle cell anemia and thalassemia are caused by HBB gene mutations, The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks, WAGR syndrome and Denys-Drash syndrome are associated with mutations of the WT1 gene, With approximately 135 million base pairs and 1, chromosome 11 makes up around 4% of human genomic DNA and is considered a gene and disease association dense chromosome, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11, while Wilms' tumors, 400 genes, TMEM16C is a 981 amino acid multi-pass membrane protein that is encoded by a gene which maps to chromosome 11 |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
GENX-3947 DYT23 |
| Also known as: |
TMEM16C/Anoctamin 3 Polyclonal Antibody |
| Other name: |
Anti-TMEM16C/Anoctamin 3 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
TMEM16C/Anoctamin 3 |
| Short name: |
Anti-TMEM16C/Anoctamin 3 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-TMEM16C/Anoctamin 3 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
14004 |
| Gene: |
ANO3 |
More about : ANO3 |
| Long gene name: |
anoctamin 3 |
| Synonyms gene: |
C11orf25 TMEM16C |
| Synonyms gene name: |
chromosome 11 open reading frame 25 transmembrane protein 16C |
| Synonyms name: |
transmembrane protein 16C (eight membrane-spanning domains) |
| Locus: |
11p14, 2 |
| Discovery year: |
2000-11-28 |
| GenBank acession: |
AJ300461 |
| Entrez gene record: |
63982 |
| Pubmed identfication: |
12739008 15067359 23200863 24692353 |
| RefSeq identity: |
NM_031418 |
| Classification: |
Anoctamins |
| Havana BLAST/BLAT: |
OTTHUMG00000166096 |