| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
DOCK4 |
| Specificity: |
This antibody reacts specifically with DOCK4 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human DOCK4 |
| Gene ID: |
9732 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
DOCK 4 contains an N-terminal SH3 domain, DOCK 4 functions as a guanine nucleotide exchange factor (GEF) that activates the small GTPase Rap 1 and, Defects in the gene encoding DOCK 4 result in the inactivation of Rap 1 and are, Expressed ubiquitously with highest expression in prostate, Four isoforms of DOCK 4 are expressed due to alternative splicing events, Similar to other DOCK family members, a C-terminal proline-rich region and two internal DOCK homology regions designated DHR1 and DHR2, glioma and colorectal carcinomas, implicated in the pathogenesis of various cancers such as ovarian, ovary and skeletal muscle, plays a role in the regulation of adherens junctions between cells, prostate, thus, via this activation, DOCK 4 is a cytoplasmic peripheral membrane protein that belongs to the DOCK family of cytokinesis-regulating proteins |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
FLJ34238 KIAA0716 |
| Also known as: |
DOCK4 Polyclonal Antibody |
| Other name: |
Anti-DOCK4 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
DOCK4 |
| Short name: |
Anti-DOCK4 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-dedicator on cytokinesis 4 (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
DOCK4 and IDBG-36595 and ENSG00000128512 and 9732, DOCK4 and IDBG-632981 and ENSBTAG00000021182 and 534227, Dock4 and IDBG-136539 and ENSMUSG00000035954 and 238130, Plasma membranes, Rac GTPase binding, this GO :0005085 and guanyl-nucleotide exchange factor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005622 and intracellular and cellular component this GO :0005829 and cytosol and cellular component this GO :0007165 and signal transduction and biological process this GO :0007264 and small GTPase mediated signal transduction and biological process this GO :0012505 and endomembrane system and cellular component this GO :0016020 and membrane and cellular component this GO :0017124 and SH3 domain binding and molecular function this GO :0030165 and PDZ domain binding and molecular function this GO :0030675 and Rac GTPase activator activity and molecular function this GO :0030971 and receptor tyrosine kinase binding and molecular function this GO :0032420 and stereocilium and cellular component this GO :0032421 and stereocilium bundle and cellular component this GO :0032855 and positive regulation of Rac GTPase activity and biological process this GO :0043547 and positive regulation of GTPase activity and biological process this GO :0048365 and Rac GTPase binding and molecular function this GO :0060326 and cell chemotaxis and biological process, this GO :0005085 : guanyl-nucleotide exchange factor activity, this GO :0005085 : guanyl-nucleotide exchange factor activity and also this GO :0005515 : protein binding and also this GO :0017124 : SH3 domain binding and also this GO :0030165 : PDZ domain binding and also this GO :0030675 : Rac GTPase activator activity and also this GO :0030971 : receptor tyrosine kinase binding and also this GO :0048365 : Rac GTPase binding, this GO :0005515 : protein binding, this GO :0017124 : SH3 domain binding, this GO :0030165 : PDZ domain binding, this GO :0030675 : Rac GTPase activator activity, this GO :0030971 : receptor tyrosine kinase binding, this GO :0048365 : Rac GTPase binding, dedicator of cytokinesis 4 |
| Identity: |
19192 |
| Gene: |
DOCK4 |
More about : DOCK4 |
| Long gene name: |
dedicator of cytokinesis 4 |
| Locus: |
7q31, 1 |
| Discovery year: |
2003-11-19 |
| Entrez gene record: |
9732 |
| Pubmed identfication: |
12432077 12628187 |
| RefSeq identity: |
NM_014705 |
| Havana BLAST/BLAT: |
OTTHUMG00000155077 |