| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
RASSF1 |
| Specificity: |
This antibody reacts specifically with RASSF1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Nucleus, Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human RASSF1 |
| Gene ID: |
11186 |
| Swiss Prot: |
Q9NS23 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
APC, DAXX and USP7, Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein, Isoform A disrupts interactions among MDM2, Isoform A interacts with CDC2, Isoform C has been shown not to perform these roles, Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation, Required for death receptor-dependent apoptosis, When associated with MOAP1, an activator of the anaphase-promoting complex, no function has been identified for this isoform, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF1 stimulation, resulting in the inhibition of APC activity and mitotic progression, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage, Potential tumor suppressor |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
NORE2A REH3P21 RDA32 123F2 |
| Also known as: |
RASSF1 Polyclonal Antibody |
| Other name: |
Anti-RASSF1 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
RASSF1 |
| Short name: |
Anti-RASSF1 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-RASSF1 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
9882 |
| Gene: |
RASSF1 |
More about : RASSF1 |
| Long gene name: |
Ras association domain family member 1 |
| Synonyms gene name: |
Ras association (RalGDS/AF-6) domain family member 1 |
| Locus: |
3p21, 31 |
| Discovery year: |
2000-05-30 |
| GenBank acession: |
AF132675 |
| Entrez gene record: |
11186 |
| Classification: |
Ras association domain family |
| Havana BLAST/BLAT: |
OTTHUMG00000149958 |