| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
SPG21 |
| Specificity: |
This antibody reacts specifically with SPG21 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human SPG21 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Belonging to the AB hydrolase superfamily, Defects in the gene encoding Maspardin are the result of hereditary spastic paraplegia autosomal recessive type 21 (also designated Mast syndrome), It is thought that Maspardin may act as a negative regulatory factor in CD4-dependent T-cell activation, Maspardin colocalizes with CD4 on endosomal/trans-Golgi network, The gene encoding Maspardin is encoded by human chromosome 15, an autosomal recessive neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs, which houses over 700 genes and comprises nearly 3% of the human genome, Maspardin is a 308 amino acid cytoplasmic protein that is widely expressed |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
ACP33 GL010 BM-019 MAST |
| Also known as: |
SPG21 Polyclonal Antibody |
| Other name: |
Anti-SPG21 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
SPG21 |
| Short name: |
Anti-SPG21 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, Mast syndrome) (polyclonal), antibody to-spastic paraplegia 21 (autosomal recessive |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
CD4 receptor binding, Mast syndrome), SPG21 and IDBG-16930 and ENSG00000090487 and 51324, SPG21 and IDBG-645311 and ENSBTAG00000011540 and 404069, Spg21 and IDBG-177905 and ENSMUSG00000032388 and 27965, nuclei, this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0008219 and cell death and biological process this GO :0010008 and endosome membrane and cellular component this GO :0030140 and trans- this GO lgi network transport vesicle and cellular component this GO :0042609 and CD4 receptor binding and molecular function this GO :0050851 and antigen receptor-mediated signaling pathway and biological process, this GO :0042609 : CD4 receptor binding, this GO :0042609 : CD4 receptor binding, spastic paraplegia 21 (autosomal recessive |
| Identity: |
20373 |
| Gene: |
SPG21 |
More about : SPG21 |
| Long gene name: |
SPG21, maspardin |
| Synonyms gene name: |
Mast syndrome) , spastic paraplegia 21 (autosomal recessive |
| Locus: |
15q22, 31 |
| Discovery year: |
2004-04-30 |
| GenBank acession: |
AF208861 |
| Entrez gene record: |
51324 |
| Pubmed identfication: |
11113139 14564668 |
| RefSeq identity: |
NM_016630 |
| Havana BLAST/BLAT: |
OTTHUMG00000133098 |