| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
TIMM8A |
| Specificity: |
This antibody reacts specifically with TIMM8A |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human TIMM8A |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Defects in Tim proteins are implicated in several neuro-degenerative diseases, Import of nuclear-encoded precursor proteins into and across the mitochondrial inner membrane is mediated by two distinct complexes, The mitochondrial Tim protein family is comprised of a large group of evolutionarily conserved proteins that are found in most eukaryotes (1, Tim8A and Tim8B, Tim8A is highly expressed in fetal and adult brain (5), Tim8A is mutated in deafness dystonia syndrome, a novel type of disease that causes severe neurological defects, are conserved proteins of the mitochondrial intermembrane space, respectively, suggesting important roles for Tim proteins in development and health (3, the Tim23 complex and the Tim22 complex, thought to be caused by a defective mitochondrial protein transport system (5, which are organized in hetero-oligomeric complex with Tim13 (5, which differ in their substrate specificity (1), which map to human chromosomes Xq22, 1 and 11q23, 1-q23, 2, 2), 4), 6, 7), 8), The majority of mitochondrial-directed proteins are encoded by the nuclear genome and are transported to the mitochondria via regulated processes involving the mitochondrial Tom and Tim proteins (1) |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
DDP MTS |
| Also known as: |
TIMM8A Polyclonal Antibody |
| Other name: |
Anti-TIMM8A Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
TIMM8A |
| Short name: |
Anti-TIMM8A (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-translocase on inner mitochondrial membrane 8 homolog A (yeast) (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
Cytoplasm, DDP and DDP1 and DFN1 and MTS and TIM8, TIMM8A and IDBG-633444 and ENSBTAG00000022292 and 515109, TIMM8A and IDBG-79593 and ENSG00000126953 and 1678, metal ion binding, this GO :0005739 and mitochondrion and cellular component this GO :0005743 and mitochondrial inner membrane and cellular component this GO :0005758 and mitochondrial intermembrane space and cellular component this GO :0006626 and protein targeting to mitochondrion and biological process this GO :0007399 and nervous system development and biological process this GO :0044267 and cellular protein metabolic process and biological process this GO :0046872 and metal ion binding and molecular function this GO :0072321 and chaperone-mediated protein transport and biological process, this GO :0046872 : metal ion binding, this GO :0046872 : metal ion binding, translocase of inner mitochondrial membrane 8 homolog A (yeast) |
| Identity: |
11817 |
| Gene: |
TIMM8A |
More about : TIMM8A |
| Long gene name: |
translocase of inner mitochondrial membrane 8A |
| Synonyms gene: |
DFN1 |
| Synonyms gene name: |
translocase of inner mitochondrial membrane 8 (yeast) homolog A translocase of inner mitochondrial membrane 8 homolog A (yeast) |
| Locus: |
Xq22, 1 |
| Discovery year: |
1999-12-01 |
| GenBank acession: |
U66035 |
| Entrez gene record: |
1678 |
| Pubmed identfication: |
10552927 8841189 |
| RefSeq identity: |
NM_004085 |
| Havana BLAST/BLAT: |
OTTHUMG00000022028 |