| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Aph-1b |
| Specificity: |
This antibody reacts specifically with Aph-1b |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human Aph-1b |
| Gene ID: |
83464 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Aph-1b and Aph-1a are splice variants of Aph-1, Aph-1b expression and Gamma-secretase activity may be implicated in neurodevelopmental disorders, Aph-1b may execute redundant functions in the cell, Aph-1b specifically lacks exon 4, Deficiency of Aph-1a causes a reduction in Gamma-secretase activity, This enzyme complex is necessary for the intra-membrane proteolysis of several different membrane proteins, and is involved in multiple neurodevelopmental signaling pathways, causing the protein to be destabilized, however deficiency of Aph-1b does not, including the beta-Amyloid precursor protein, seven-pass membrane protein that functions as one of the four essential components in the presenilin-Gamma-secretase enzyme complex, such as schizophrenia, thus, which encodes for the entire fourth transmembrane domain, Anterior pharynx defective 1 (Aph-1) is a polytopic |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
PSFL APH-1B DKFZp564D0372 |
| Also known as: |
Aph-1b Polyclonal Antibody |
| Other name: |
Anti-Aph-1b Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
Aph-1b |
| Short name: |
Anti-Aph-1b (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Aph-1b (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
24080 |
| Gene: |
APH1B |
More about : APH1B |
| Long gene name: |
aph-1 homolog B, gamma-secretase subunit |
| Synonyms gene name: |
anterior pharynx defective 1 homolog B (C, elegans) APH1B gamma secretase subunit |
| Locus: |
15q22, 2 |
| Discovery year: |
2005-02-08 |
| GenBank acession: |
AY358698 |
| Entrez gene record: |
83464 |
| Pubmed identfication: |
12110170 11230166 |
| RefSeq identity: |
NM_031301 |
| Havana BLAST/BLAT: |
OTTHUMG00000132863 |