| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
SOX8 |
| Specificity: |
This antibody reacts specifically with SOX8 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human SOX8 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
30 Sox genes have been identified, At present, Members of this family have been shown to be conserved during evolution and to play key roles during animal development, Some are involved in human diseases, Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes, The highly complex group of Sox genes cluster at least 40 different loci that rapidly diverged in various animal lineages, These genes similarly contain sequences that encode for the HMG-box domain, including sex reversal, which is responsible for the sequence-specific DNA-binding activity, Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Also known as: |
SOX8 Polyclonal Antibody |
| Other name: |
Anti-SOX8 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
SOX8 |
| Short name: |
Anti-SOX8 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-SRY (sex determining region Y)-box 8 (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
DNA-templated and biological process this GO :0006366 and transcription from RNA polymerase II promoter and biological process this GO :0007165 and signal transduction and biological process this GO :0007283 and spermatogenesis and biological process this GO :0007422 and peripheral nervous system development and biological process this GO :0008134 and transcription factor binding and molecular function this GO :0008584 and male this GO nad development and biological process this GO :0010628 and positive regulation of gene expression and biological process this GO :0010817 and regulation of hormone levels and biological process this GO :0014015 and positive regulation of gliogenesis and biological process this GO :0033690 and positive regulation of osteoblast proliferation and biological process this GO :0035914 and skeletal muscle cell differentiation and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043565 and sequence-specific DNA binding and molecular function this GO :0044798 and nuclear transcription factor complex and cellular component this GO :0045165 and cell fate commitment and biological process this GO :0045444 and fat cell differentiation and biological process this GO :0045662 and negative regulation of myoblast differentiation and biological process this GO :0045892 and negative regulation of transcription, DNA-templated and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046533 and negative regulation of photoreceptor cell differentiation and biological process this GO :0046982 and protein heterodimerization activity and molecular function this GO :0048469 and cell maturation and biological process this GO :0048484 and enteric nervous system development and biological process this GO :0048709 and oli this GO dendrocyte differentiation and biological process this GO :0060009 and Sertoli cell development and biological process this GO :0060018 and astrocyte fate commitment and biological process this GO :0060041 and retina development in camera-type eye and biological process this GO :0060221 and retinal rod cell differentiation and biological process this GO :0060612 and adipose tissue development and biological process this GO :0061138 and morphogenesis of a branching epithelium and biological process this GO :0072034 and renal vesicle induction and biological process this GO :0072197 and ureter morphogenesis and biological process this GO :0072289 and metanephric nephron tubule formation and biological process this GO :0090184 and positive regulation of kidney development and biological process this GO :0090190 and positive regulation of branching involved in ureteric bud morphogenesis and biological process, SOX8 and IDBG-634123 and ENSBTAG00000020737 and 530317, SOX8 and IDBG-8450 and ENSG00000005513 and 30812, Sox8 and IDBG-152312 and ENSMUSG00000024176 and 20681, nuclei, protein heterodimerization activity, this GO :0000979 and RNA polymerase II core promoter sequence-specific DNA binding and molecular function this GO :0000981 and sequence-specific DNA binding RNA polymerase II transcription factor activity and molecular function this GO :0001649 and osteoblast differentiation and biological process this GO :0001701 and in utero embryonic development and biological process this GO :0001755 and neural crest cell migration and biological process this GO :0003677 and DNA binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0006351 and transcription, this GO :0000979 : RNA polymerase II core promoter sequence-specific DNA binding, this GO :0000979 : RNA polymerase II core promoter sequence-specific DNA binding and also this GO :0000981 : sequence-specific DNA binding RNA polymerase II transcription factor activity and also this GO :0003677 : DNA binding and also this GO :0003700 : sequence-specific DNA binding transcription factor activity and also this GO :0005515 : protein binding and also this GO :0008134 : transcription factor binding and also this GO :0043565 : sequence-specific DNA binding and also this GO :0046982 : protein heterodimerization activity, this GO :0000981 : sequence-specific DNA binding RNA polymerase II transcription factor activity, this GO :0003677 : DNA binding, this GO :0003700 : sequence-specific DNA binding transcription factor activity, this GO :0005515 : protein binding, this GO :0008134 : transcription factor binding, this GO :0043565 : sequence-specific DNA binding, this GO :0046982 : protein heterodimerization activity, SRY (sex determining region Y)-box 8 |
| Identity: |
11203 |
| Gene: |
SOX8 |
More about : SOX8 |
| Long gene name: |
SRY-box 8 |
| Synonyms gene name: |
SRY (sex determining region Y)-box 8 SRY box 8 |
| Locus: |
16p13, 3 |
| Discovery year: |
2000-03-14 |
| GenBank acession: |
AF164104 |
| Entrez gene record: |
30812 |
| Pubmed identfication: |
10662550 10684944 |
| Classification: |
SRY-boxes |
| Havana BLAST/BLAT: |
OTTHUMG00000122101 |