| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
PHOX2A/CFEOM2 |
| Specificity: |
This antibody reacts specifically with PHOX2A/CFEOM2 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human PHOX2A |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
All enteric nervous system cells evolve from the neural crest, Both Phox2a and Phox2b are crucial for the regulation of endogenous tyrosine hydroxylase and dopamine-beta hydroxylase, In addition, In contrast, Phox2 proteins are sufficient to promote sympathetic neuron generation, Phox2a controls only the differentiation of the main noradrenergic center of the brain, Phox2b is required for the differentiation of all central and nonperipheral noradrenergic centers in the brain, The cells that begin to differentiate along a neuronal lineage continue to express Phox2b, The gene which encodes Phox2a maps to human chromosome 11q13, and all cells that are undifferentiated initially express Phox2b, and begin to express Phox2a, paired-homeodomain transcription factors that are necessary for neuronal differentiation throughout the developing sympathetic, parasympathetic and enteric ganglia, the locus ceruleus, which are transiently expressed in neural crest cells, 3-q13, 4, Phox2a (also designated Arix1) and Phox2b are closely related |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
PMX2A CFEOM2 |
| Also known as: |
PHOX2A/CFEOM2 Polyclonal Antibody |
| Other name: |
Anti-PHOX2A/CFEOM2 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
PHOX2A/CFEOM2 |
| Short name: |
Anti-PHOX2A/CFEOM2 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-PHOX2A/CFEOM2 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
691 |
| Gene: |
PHOX2A |
More about : PHOX2A |
| Long gene name: |
paired like homeobox 2a |
| Synonyms gene: |
ARIX FEOM2 |
| Synonyms gene name: |
2, aristaless (Drosophila) homeobox, aristaless homeobox (Drosophila), autosomal recessive paired-like (aristaless) homeobox 2a , congenital, fibrosis of extraocular muscles |
| Locus: |
11q13, 4 |
| Discovery year: |
1995-12-11 |
| GenBank acession: |
AF022722 |
| Entrez gene record: |
401 |
| Pubmed identfication: |
8661014 11600883 |
| RefSeq identity: |
NM_005169 |
| Classification: |
PRD class homeoboxes and pseudogenes |
| Havana BLAST/BLAT: |
OTTHUMG00000167899 |