| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
CSN7b |
| Specificity: |
This antibody reacts specifically with CSN7b |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human CSN7b |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
COPS7a) or CSN7b (COP7b) and CSN8 (COP8), CSN2 (COPS2), CSN3, CSN3 (COPS3), CSN4, CSN4 (COPS4), CSN5, CSN5 (COPS5), CSN6, CSN6 (COP6), CSN7 is phosphorylated by CK2 and is composed of two subunits, CSN7a (COPS7, CSN7a contains a PCI (Proteasome CSN9 initiation factor 3) region, CSN7b contains only a PCI region and is predicted to interact with INT6, CSN8, I&, It is also involved in the phosphorylation of p53, The CSN complex acts as a regulator for the ubiquitin conjugation pathway by mediating the deneddylation of the SCF-type E3 ligase complexes, The complex is made up of several widely expressed proteins: CSN1 (COPS1), a and b, and GPS1, and IRF-8, and c-Jun protects and promotes degradation by the Ubl system, as well as CSN-dependent phosphorylation of p53, as well as a coiled-coil region and is predicted to interact with CSN2, c-Jun, which leads to a decrease in ubiquitin ligase activity of SCF-complexes, #730, B&, The COP9 signalosome (CSN) complex is involved in several different developmental and cellular processes, aring |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
CSN7B |
| Also known as: |
CSN7b Polyclonal Antibody |
| Other name: |
Anti-CSN7b Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
CSN7b |
| Short name: |
Anti-CSN7b (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-CSN7b (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
16760 |
| Gene: |
COPS7B |
More about : COPS7B |
| Long gene name: |
COP9 signalosome subunit 7B |
| Synonyms gene name: |
Arabidopsis, COP9 (constitutive photomorphogenic, homolog) subunit 7B COP9 constitutive photomorphogenic homolog subunit 7B (Arabidopsis) |
| Locus: |
2q37, 1 |
| Discovery year: |
2001-10-03 |
| GenBank acession: |
AK022674 |
| Entrez gene record: |
64708 |
| Pubmed identfication: |
9707402 |
| RefSeq identity: |
NM_022730 |
| Classification: |
COP9 signalosome |
| Havana BLAST/BLAT: |
OTTHUMG00000133228 |