| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
GALR3 |
| Specificity: |
This antibody reacts specifically with GALR3 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human GALR3 |
| Gene ID: |
8484 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Binding of galanin to galanin receptors results in increased feeding, GALR3 mRNA is highly expressed in the hypothalamus, GALR3 mRNA is widely distributed, GALR3 signaling pathways lead to the inhibition of adenylate cyclase and to the activation of potassium channels, In human, Like GALR1, Rat and human GALR3 co-express with potassium channel subunits GIRK1 and GIRK4, and is expressed to a lesser extent in adrenal gland and pancreas, belongs to a family of G protein-coupled receptors that bind the neuropeptide galanin, but expressed at low abundance, enhanced opiate analgesia and decreased opiate place preference, impaired learning, pituitary and testis, respectively, the gastrointestinal tract and in the endocrine and exocrine pancreas, the pituitary gland, which are linked to the regulation of neurotransmitter release, which is distributed throughout the central and peripheral nervous system, GALR3 a 368 and 370 amino acid protein in human and rat |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Also known as: |
GALR3 Polyclonal Antibody |
| Other name: |
Anti-GALR3 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
GALR3 |
| Short name: |
Anti-GALR3 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-GALR3 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
4134 |
| Gene: |
GALR3 |
More about : GALR3 |
| Long gene name: |
galanin receptor 3 |
| Locus: |
22q13, 1 |
| Discovery year: |
1998-12-17 |
| GenBank acession: |
AF073799 |
| Entrez gene record: |
8484 |
| Pubmed identfication: |
9722565 9832121 |
| Classification: |
Galanin receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000150658 |