| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
CDH18 |
| Specificity: |
This antibody reacts specifically with CDH18 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human CDH18 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
CDH14 (cadherin 14), CDH24 or CDH14L, EY-cadherin, EY-cadherin contains a highly conserved C-terminal domain characteristic of all cadherins, EY-cadherin functions as a type II classical cadherin that is expressed specifically in the central nervous system (CNS), EY-cadherin is thought to be involved in axon guidance and outgrowth, One of several members of the cadherin superfamily, Specifically, The gene encoding EY-cadherin is located within a region on chromosome five that is commonly deleted in carcinomas, also known as CDH18 (cadherin 18), as well as synaptic adhesion within the CNS, but lacks the HAV cell adhesion sequence that is specific to type I cadherins, implicating EY-cadherin as a potential tumor suppressor, is a 790 amino acid single-pass type I membrane protein that contains five cadherin domains, where it plays a role in cell-cell binding events, The cadherins are a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding events that are critical to the maintenance of cell structure and morphogenesis |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
CDH14 EY-CADHERIN |
| Also known as: |
CDH18 Polyclonal Antibody |
| Other name: |
Anti-CDH18 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
CDH18 |
| Short name: |
Anti-CDH18 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, classification 2 (polyclonal), antibody to-cadherin 18 |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
CDH14 and CDH14L and CDH24, CDH18 and IDBG-13642 and ENSG00000145526 and 1016, CDH18 and IDBG-631065 and ENSBTAG00000037844 and 512080, Cdh18 and IDBG-130778 and ENSMUSG00000040420 and 320865, Plasma membranes, calcium ion binding, this GO :0005509 and calcium ion binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0007156 and homophilic cell adhesion and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0034329 and cell junction assembly and biological process this GO :0034332 and adherens junction organization and biological process this GO :0045216 and cell-cell junction organization and biological process, this GO :0005509 : calcium ion binding, this GO :0005509 : calcium ion binding, type 2, cadherin 18 |
| Identity: |
1757 |
| Gene: |
CDH18 |
More about : CDH18 |
| Long gene name: |
cadherin 18 |
| Synonyms gene name: |
cadherin 18, type 2 |
| Locus: |
5p14, 3 |
| Discovery year: |
1997-06-25 |
| GenBank acession: |
U59325 |
| Entrez gene record: |
1016 |
| Pubmed identfication: |
9030594 10191097 |
| RefSeq identity: |
NM_004934 |
| Classification: |
Type II classical cadherins |
| Havana BLAST/BLAT: |
OTTHUMG00000090578 |