| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
PSCDBP/CYTIP |
| Specificity: |
This antibody reacts specifically with PSCDBP/CYTIP |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human PSCDBP/CYTIP |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Additionally, After membrane translocation, CYTIP associates with SNX27 (sorting nexin 27) and helps to coordinate trafficking and signaling complexes, CYTIP can be re-located to the cytoplasm via exposure to a phorbol ester, CYTIP can be recruited from the cytoplasm to the membrane by leukocyte integrins which interact with CYTIP through its PDZ domain, CYTIP is able to sequester it to the cytoplasm, CYTIP regulates the activity of cytohesin-1 (an integrin-activating protein involved in cell adhesion) by mediating its recruitment to the leukocyte membrane, Expressed primarily in hematopoetic cells, Through its ability to bind cytohesin-1, Up-regulation of CYTIP is observed in maturing dendritic cells, suggesting a possible role in developmentally-controlled cell adhesion, thereby preventing cytohesin-1 translocation to lymphocytes and interrupting the flow of information in the cell adhesion pathway, CYTIP is a cytoplasmic protein that is involved in lymphocytic cell adhesion |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
B3-1 HE CYBR CASP CYTHIP |
| Also known as: |
PSCDBP/CYTIP Polyclonal Antibody |
| Other name: |
Anti-PSCDBP/CYTIP Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
PSCDBP/CYTIP |
| Short name: |
Anti-PSCDBP/CYTIP (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-PSCDBP/cytohesin 1 interacting protein (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
B3-1 and CASP and CYBR and CYTHIP and HE and PSCDBP, CYTIP and IDBG-641611 and ENSBTAG00000008329 and 540450, CYTIP and IDBG-72874 and ENSG00000115165 and 9595, Cytip and IDBG-171958 and ENSMUSG00000026832 and 227929, nuclei, protein binding, this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005769 and early endosome and cellular component this GO :0005938 and cell cortex and cellular component this GO :0030155 and regulation of cell adhesion and biological process this GO :0045087 and innate immune response and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding, cytohesin 1 interacting protein |
| Identity: |
9506 |
| Gene: |
CYTIP |
More about : CYTIP |
| Long gene name: |
cytohesin 1 interacting protein |
| Synonyms gene: |
PSCDBP |
| Synonyms gene name: |
Sec7 and coiled-coil domains, binding protein , pleckstrin homology |
| Synonyms name: |
cytohesin binding protein HE cytohesin binder and regulator |
| Locus: |
2q24, 1 |
| Discovery year: |
1999-07-19 |
| GenBank acession: |
L06633 |
| Entrez gene record: |
9595 |
| Pubmed identfication: |
18926288 10343115 11867758 20530790 21562043 |
| RefSeq identity: |
NM_004288 |
| Classification: |
PDZ domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000154551 |