| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
HEXB chain A |
| Specificity: |
This antibody reacts specifically with HEXB chain A |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human HEXB chain A |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Beta subunit gene mutations lead to Sandhoff disease (GM2-gangliosidosis type II), Beta-hexosaminidase is composed of two subunits, Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases, Jul 2008], Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses, [provided by RefSeq, alpha and beta, and other molecules containing terminal N-acetyl hexosamines, catalyzes the degradation of the ganglioside GM2, together with the cofactor GM2 activator protein, which are encoded by separate genes, Hexosaminidase B is the beta subunit of the lysosomal enzyme beta-hexosaminidase that |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Also known as: |
HEXB chain A Polyclonal Antibody |
| Other name: |
Anti-HEXB chain A Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
HEXB chain A |
| Short name: |
Anti-HEXB chain A (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-HEXB epitope A (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
4879 |
| Gene: |
HEXB |
More about : HEXB |
| Long gene name: |
hexosaminidase subunit beta |
| Synonyms gene name: |
hexosaminidase B (beta polypeptide) |
| Synonyms name: |
beta-hexosaminidase subunit beta |
| Locus: |
5q13, 3 |
| Discovery year: |
2001-06-22 |
| GenBank acession: |
M13519 |
| Entrez gene record: |
3074 |
| Pubmed identfication: |
2579389 3013851 |
| RefSeq identity: |
NM_000521 |
| Havana BLAST/BLAT: |
OTTHUMG00000102057 |
| Locus Specific Databases: |
HEXB Locus Database |