| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
CIITA |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, IHC (FFPE): 1-2ug/ml, Western blot: 0 |
| Added buffer: |
025% sodium azide, 5% BSA and 0, Lyophilized from 1X Phosphate Buffered Saline (PBS) with 2 |
| Intented use: |
This CIITA antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P33076 |
| Purity: |
Antigen affinity |
| Description: |
4 LRRs (leucine-rich repeats) and a GTP binding domain, Also, Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion, Several transcript variants encoding different isoforms have been found for this gene, The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, This gene encodes a protein with an acidic transcriptional activation domain, and is referred to as the master control factor for the expression of these genes, and possibly myocardial infarction, increased susceptibility to rheumatoid arthritis, multiple sclerosis, the protein binds GTP and uses GTP binding to facilitate its own transport into the nucleus, CIITA is a human gene which is mapped to 16p13 |
| Immunogen: |
Amino acids E945-R1130 from the human protein were used as the immunogen for the CIITA antibody |
| Storage: |
After reconstitution, Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, store at 4oC, the CIITA antibody may be kept for up to one month refrigerated at +4 degrees C, For long-term, Prior to reconstitution |
| Localization: |
Nuclear |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
CIITA |
| Short name: |
CIITA Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
major histocompatibility complex, transactivator (Antibody to), class II |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
C2TA and CIITAIV and MHC2TA and NLRA, CIITA and IDBG-14377 and ENSG00000179583 and 4261, CIITA and IDBG-636856 and ENSBTAG00000020649 and, Ciita and IDBG-132343 and ENSMUSG00000022504 and 12265, DNA-templated and biological process this GO :0006355 and regulation of transcription, DNA-templated and biological process this GO :0006954 and inflammatory response and biological process this GO :0006955 and immune response and biological process this GO :0007568 and aging and biological process this GO :0008022 and protein C-terminus binding and molecular function this GO :0009986 and cell surface and cellular component this GO :0016301 and kinase activity and molecular function this GO :0016310 and phosphorylation and biological process this GO :0016605 and PML body and cellular component this GO :0016746 and transferase activity, DNA-templated and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046677 and response to antibiotic and biological process this GO :0060333 and interferon-gamma-mediated signaling pathway and biological process this GO :0071257 and cellular response to electrical stimulus and biological process this GO :0071346 and cellular response to interferon-gamma and biological process this GO :0071360 and cellular response to exogenous dsRNA and biological process, major histocompatibility complex, nuclei, this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0003713 and transcription coactivator activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005525 and GTP binding and molecular function this GO :0005654 and nucleoplasm and cellular component this GO :0006351 and transcription, this GO :0003713 : transcription coactivator activity, this GO :0003713 : transcription coactivator activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0005525 : GTP binding and also this GO :0008022 : protein C-terminus binding and also this GO :0016301 : kinase activity and also this GO :0016746 : transferase activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0005525 : GTP binding, this GO :0008022 : protein C-terminus binding, this GO :0016301 : kinase activity, this GO :0016746 : transferase activity, this GO :0032403 : protein complex binding, this GO :0033613 : activating transcription factor binding, this GO :0044212 : transcription regulatory region DNA binding, transactivator, transferase activity, transferring acyl groups, transferring acyl groups and also this GO :0032403 : protein complex binding and also this GO :0033613 : activating transcription factor binding and also this GO :0044212 : transcription regulatory region DNA binding, transferring acyl groups and molecular function this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0032403 and protein complex binding and molecular function this GO :0032966 and negative regulation of collagen biosynthetic process and biological process this GO :0033613 and activating transcription factor binding and molecular function this GO :0034341 and response to interferon-gamma and biological process this GO :0044212 and transcription regulatory region DNA binding and molecular function this GO :0045345 and positive regulation of MHC class I biosynthetic process and biological process this GO :0045348 and positive regulation of MHC class II biosynthetic process and biological process this GO :0045892 and negative regulation of transcription, class II |
| Identity: |
7067 |
| Gene: |
CIITA |
More about : CIITA |
| Long gene name: |
class II major histocompatibility complex transactivator |
| Synonyms gene: |
MHC2TA |
| Synonyms gene name: |
MHC class II transactivator class II, major histocompatibility complex, transactivator |
| Synonyms: |
C2TA NLRA |
| Synonyms name: |
NLR family, acid domain containing nucleotide-binding oligomerization domain, leucine rich repeat and acid domain containing |
| Locus: |
16p13, 13 |
| Discovery year: |
1997-06-12 |
| GenBank acession: |
U18259 |
| Entrez gene record: |
4261 |
| Pubmed identfication: |
8402893 |
| RefSeq identity: |
NM_000246 |
| Classification: |
NLR family |
| Havana BLAST/BLAT: |
OTTHUMG00000129753 |
| Locus Specific Databases: |
CIITAbase: Mutation registry for MHCII transactivating protein deficiency (previously known as MHC2TAbase) LRG_49 |