| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
MERTK |
| Specificity: |
This antibody reacts specifically with MERTK |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human of human MERTK |
| Gene ID: |
10461 |
| Swiss Prot: |
Q12866 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
FAK/PTK2 or RAC1, Following activation by ligand, Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis, Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules, MAPK2, MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, Regulates many physiological processes including cell survival, TUB, TULP1 or GAS6, and phagocytosis of apoptotic cells (efferocytosis), cytoskeleton reorganization and engulfment, differentiation, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, migration, platelet aggregation, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3, Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3 |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
mer RP38 c-Eyk Tyro12 |
| Also known as: |
MERTK Polyclonal Antibody |
| Other name: |
Anti-MERTK Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
MERTK |
| Short name: |
Anti-MERTK (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-c-mer proto-oncogene tyrosine kinase (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
Extracellular, MERTK and IDBG-628865 and ENSBTAG00000005828 and 504429, MERTK and IDBG-66030 and ENSG00000153208 and 10461, Mertk and IDBG-205458 and ENSMUSG00000014361 and 17289, c-mer and MER and RP38, this GO :0001750 and photoreceptor outer segment and cellular component this GO :0001779 and natural killer cell differentiation and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0004714 and transmembrane receptor protein tyrosine kinase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005615 and extracellular space and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006909 and pha this GO cytosis and biological process this GO :0007166 and cell surface receptor signaling pathway and biological process this GO :0007267 and cell-cell signaling and biological process this GO :0007283 and spermatogenesis and biological process this GO :0007596 and blood coagulation and biological process this GO :0016021 and integral component of membrane and cellular component this GO :0016028 and rhabdomere and cellular component this GO :0016772 and transferase activity, this GO :0004672 : protein kinase activity, this GO :0004672 : protein kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0004714 : transmembrane receptor protein tyrosine kinase activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0016772 : transferase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0004714 : transmembrane receptor protein tyrosine kinase activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0016772 : transferase activity, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups, transferring phosphorus-containing groups and molecular function this GO :0018108 and peptidyl-tyrosine phosphorylation and biological process this GO :0030168 and platelet activation and biological process this GO :0032940 and secretion by cell and biological process this GO :0034446 and substrate adhesion-dependent cell spreading and biological process this GO :0043277 and apoptotic cell clearance and biological process this GO :0043491 and protein kinase B signaling and biological process this GO :0045087 and innate immune response and biological process this GO :0050766 and positive regulation of pha this GO cytosis and biological process this GO :0050900 and leukocyte migration and biological process this GO :0051250 and negative regulation of lymphocyte activation and biological process this GO :0060041 and retina development in camera-type eye and biological process this GO :0060068 and vagina development and biological process, c-mer proto-oncogene tyrosine kinase |
| Identity: |
7027 |
| Gene: |
MERTK |
More about : MERTK |
| Long gene name: |
MER proto-oncogene, tyrosine kinase |
| Synonyms gene name: |
c-mer proto-oncogene tyrosine kinase |
| Locus: |
2q13 |
| Discovery year: |
1998-11-30 |
| GenBank acession: |
U08023 |
| Entrez gene record: |
10461 |
| Pubmed identfication: |
8086340 10343112 |
| Classification: |
I-set domain containing Immunoglobulin like domain containing Fibronectin type III domain containing Receptor Tyrosine Kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000131278 |
| Locus Specific Databases: |
Mutations of the MER Receptor Tyrosine Kinase Gene |