| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
FRZB |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, WB |
| Recommended dilutions: |
request BSA-free format for coating, 1-0, 1-0, 5ug/ml, 5ug/ml (human protein tested), ELISA: 0, Western blot: 0 |
| Notes: |
Optimal dilution of the FRZB antibody should be determined by the researcher |
| Intented use: |
This FRZB antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q92765 |
| Purity: |
Antigen affinity |
| Description: |
Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility, FRZB is a Wnt-binding protein especially important in embryonic development, FRZB is localized in the extracellular plasma membrane, It is a competitor for the cell-surface G-protein receptor Frizzled, It is still considered a homolog of frizzled because it contains a Cysteine Rich Domain (CRD), The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development, Unlike frizzled, and because of its intracellular C-terminus which is crucial for signaling, frzb lacks the 7 transmembrane domains normally found in G-protein-coupled receptors, FRZB is also known as FRE or OS1 |
| Immunogen: |
Amino acids 176-325 of human FRZB were used as the immunogen for the FRZB antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the FRZB antibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
FRZB |
| Short name: |
FRZB Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
frizzled-related protein (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Extracellular, FRE and FRITZ and FRP-3 and FRZB-1 and FRZB-PEN and FRZB1 and FZRB and hFIZ and OS1 and SFRP3 and SRFP3, FRZB and IDBG-639871 and ENSBTAG00000010977 and 281170, FRZB and IDBG-76878 and ENSG00000162998 and 2487, Frzb and IDBG-183775 and ENSMUSG00000027004 and 20378, Wnt-activated receptor activity, this GO :0001501 and skeletal system development and biological process this GO :0001944 and vasculature development and biological process this GO :0005515 and protein binding and molecular function this GO :0005615 and extracellular space and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0007420 and brain development and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0008406 and this GO nad development and biological process this GO :0010721 and negative regulation of cell development and biological process this GO :0014033 and neural crest cell differentiation and biological process this GO :0016020 and membrane and cellular component this GO :0016055 and Wnt signaling pathway and biological process this GO :0017147 and Wnt-protein binding and molecular function this GO :0030165 and PDZ domain binding and molecular function this GO :0030178 and negative regulation of Wnt signaling pathway and biological process this GO :0030308 and negative regulation of cell growth and biological process this GO :0042472 and inner ear morphogenesis and biological process this GO :0042813 and Wnt-activated receptor activity and molecular function this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0045600 and positive regulation of fat cell differentiation and biological process this GO :0060029 and convergent extension involved in organogenesis and biological process this GO :0060056 and mammary gland involution and biological process this GO :0060429 and epithelium development and biological process this GO :0061037 and negative regulation of cartilage development and biological process this GO :0061053 and somite development and biological process this GO :0070367 and negative regulation of hepatocyte differentiation and biological process this GO :0090090 and negative regulation of canonical Wnt signaling pathway and biological process this GO :0090103 and cochlea morphogenesis and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding and also this GO :0017147 : Wnt-protein binding and also this GO :0030165 : PDZ domain binding and also this GO :0042813 : Wnt-activated receptor activity, this GO :0017147 : Wnt-protein binding, this GO :0030165 : PDZ domain binding, this GO :0042813 : Wnt-activated receptor activity, frizzled-related protein |
| Identity: |
3959 |
| Gene: |
FRZB |
More about : FRZB |
| Long gene name: |
frizzled-related protein |
| Synonyms: |
FRZB-PEN FRZB1 SRFP3 FRP-3 SFRP3 FRE FRITZ FRZB-1 FZRB hFIZ |
| Synonyms name: |
secreted frizzled-related protein 3 |
| Locus: |
2q32, 1 |
| Discovery year: |
1998-07-15 |
| GenBank acession: |
U24163 |
| Entrez gene record: |
2487 |
| Pubmed identfication: |
8824257 9118218 |
| RefSeq identity: |
NM_001463 |
| Classification: |
Secreted frizzled-related proteins |
| Havana BLAST/BLAT: |
OTTHUMG00000132597 |