| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
DDB2 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
1-0, 5ug/ml, Western blot: 0 |
| Notes: |
Optimal dilution of the DDB2 antibody should be determined by the researcher |
| Intented use: |
This DDB2 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q92466 |
| Purity: |
Antigen affinity |
| Description: |
And this subunit appears to be required for DNA binding, Mutations in this gene cause xeroderma pigmentosum complementation group E, This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA, This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, Two transcript variants encoding different isoforms have been found for this gene, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, and this complex mediates the ubiquitylation of histones H3 and H4, in some cases accompanied by neurological abnormalities, which facilitates the cellular response to DNA damage, DNA damage-binding protein 2 is a protein that in humans is encoded by the DDB2 gene |
| Immunogen: |
Amino acids 1-115 of human DDB2 were used as the immunogen for the DDB2 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the DDB2 antibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
DDB2 |
| Short name: |
DDB2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
DDB2 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
2718 |
| Gene: |
DDB2 |
More about : DDB2 |
| Long gene name: |
damage specific DNA binding protein 2 |
| Synonyms gene name: |
damage-specific DNA binding protein 2 (48kD) |
| Synonyms: |
DDBB UV-DDB2 FLJ34321 XPE |
| Synonyms name: |
xeroderma pigmentosum group E protein UV-damaged DNA-binding protein 2 DDB p48 subunit |
| Locus: |
11p11, 2 |
| Discovery year: |
1995-07-06 |
| Entrez gene record: |
1643 |
| Pubmed identfication: |
8407967 8530102 |
| RefSeq identity: |
NM_000107 |
| Classification: |
Xeroderma pigmentosum complementation groups Nucleotide excision repair WD repeat domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000187453 |
| Locus Specific Databases: |
LRG_467 |