| Long name: |
DDB2 Primary Polyclonal Antibody |
| Also known as: |
DDB2 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
DDB2 |
| Specificity: |
This antibody may have a minor secondary cross-reactivity to TNFAIP3-interacting protein 2 due to a 63% non-sequential sequence similarity in the immunogen region, This is a highly specific antibody against DDB2 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
230-270/427 |
| Subcellular location: |
Nucleus |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human DDB2 |
| Gene ID number: |
1643 |
| Swiss Prot: |
Q92466 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
6-4 photoproducts (6-4 PP), Also appears to function as the substrate recognition module for the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1), Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex), Isoform D1 and isoform D2 inhibit UV-damaged DNA repair, The DDB1-CUL4-ROC1 complex also ubiquitinates XPC, The DDB1-CUL4-ROC1 complex may ubiquitinate histone H2A, The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair, The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair, apurinic sites and short mismatches, histone H3 and histone H4 at sites of UV-induced DNA damage, which may enhance DNA-binding by XPC and promote NER, Required for DNA repair |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
DDB p48 subunit, DDB2, DNA damage-binding protein 2, Damage-specific DNA-binding protein 2, UV-DDB 2, UV-DDB2, UV-damaged DNA-binding protein 2, DDBB |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
DDB2 |
| Short name: |
DDB2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
DDB2 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
2718 |
| Gene: |
DDB2 |
More about : DDB2 |
| Long gene name: |
damage specific DNA binding protein 2 |
| Synonyms gene name: |
damage-specific DNA binding protein 2 (48kD) |
| Synonyms: |
DDBB UV-DDB2 FLJ34321 XPE |
| Synonyms name: |
xeroderma pigmentosum group E protein UV-damaged DNA-binding protein 2 DDB p48 subunit |
| Locus: |
11p11, 2 |
| Discovery year: |
1995-07-06 |
| Entrez gene record: |
1643 |
| Pubmed identfication: |
8407967 8530102 |
| RefSeq identity: |
NM_000107 |
| Classification: |
Xeroderma pigmentosum complementation groups Nucleotide excision repair WD repeat domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000187453 |
| Locus Specific Databases: |
LRG_467 |