| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
TrkB |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
1-0, 5ug/ml, Western blot: 0 |
| Notes: |
Optimal dilution of the TrkB antibody should be determined by the researcher |
| Intented use: |
This TrkB antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q16620 |
| Purity: |
Antigen affinity |
| Description: |
Alternative splicing results in multiple transcript variants, As such, Mutations in this gene have been associated with obesity and mood disorders, Signalling through this kinase leads to cell differentiation, The neurotrophins that activate TrkB are: BDNF (Brain Derived Neurotrophic Factor), This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family, This kinase is a membrane-bound receptor that, TrkB mediates the multiple effects of these neurotrophic factors, Tropomyosin receptor kinase B is the high affinity catalytic receptor for several neurotrophins, and neurotrophin-3 (NT-3), neurotrophin-4 (NT-4), phosphorylates itself and members of the MAPK pathway, upon neurotrophin binding, which are small protein growth factors that induce the survival and differentiation of distinct cell populations, which includes neuronal differentiation and survival, TrkB is also known as NTRK2 |
| Immunogen: |
Amino acids 66-242 of human TrkB were used as the immunogen for the TrkB antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the TrkB antibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
TrkB |
| Short name: |
TrkB Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
TrkB (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
8032 |
| Gene: |
NTRK2 |
More about : NTRK2 |
| Long gene name: |
neurotrophic receptor tyrosine kinase 2 |
| Synonyms gene name: |
neurotrophic tyrosine kinase, receptor, type 2 |
| Synonyms: |
TRKB |
| Locus: |
9q21, 33 |
| Discovery year: |
1991-07-18 |
| GenBank acession: |
AF410902 |
| Entrez gene record: |
4915 |
| Pubmed identfication: |
7789988 |
| Classification: |
I-set domain containing Receptor Tyrosine Kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000020120 |