| Long name: |
TrkB Primary Polyclonal Antibody |
| Also known as: |
TrkB PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
TrkB |
| Specificity: |
This is a highly specific antibody against TrkB |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
370-429/822 |
| Subcellular location: |
Extracellular |
| Source: |
KLH conjugated synthetic peptide derived from rat TrkB |
| Gene ID number: |
4915 |
| Swiss Prot: |
Q16620 |
| Tested Applications: |
FCM, IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
FCM(1:20-100), IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2, FRS2, FRS2, Hence, May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia, PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival, Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4, Recruits, SH2B1, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades, Thereby, Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity, Through SHC1, Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival, Upon ligand-binding, and synapse formation and plasticity, autophosphorylation and activation, differentiation, it is able to suppress anoikis, migration, phosphorylates and/or activates several downstream effectors including SHC1, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation, proliferation, the apoptosis resulting from loss of cell-matrix interactions, undergoes homodimerization, Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
BDNF/NT-3 growth factors receptor, GP145-TrkB, NTRK2, Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase, Tropomyosin-related kinase B, trk-B, TRKB |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
TrkB |
| Short name: |
TrkB Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
TrkB (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
8032 |
| Gene: |
NTRK2 |
More about : NTRK2 |
| Long gene name: |
neurotrophic receptor tyrosine kinase 2 |
| Synonyms gene name: |
neurotrophic tyrosine kinase, receptor, type 2 |
| Synonyms: |
TRKB |
| Locus: |
9q21, 33 |
| Discovery year: |
1991-07-18 |
| GenBank acession: |
AF410902 |
| Entrez gene record: |
4915 |
| Pubmed identfication: |
7789988 |
| Classification: |
I-set domain containing Receptor Tyrosine Kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000020120 |